Domel Susp 60ml

What it is used for: Nausea & Vomiting.

Indications as listed by the manufacturer: It is used in the treatment of nausea and vomiting.

How it works: Its anti emetic effect may be due to a combination of peripheral (gastrokinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood brain barrier in the area postrema.

Active ingredient: Domeperidone Maleate.

Reported side effects: Depression (2.5%) Anxiety (1.6%) Libido Decreased/Loss of Libido , Headache (5.6%) , Somnolence (2.5%) , Akathisia (1%) , Diarrhea (5.2%) , Rash (2.8%), Pruritus (1.7%) , Breast Enlargement / Gynaecomastia (5.3%) Breast Tenderness (4.4%), Galactorrhoea (3.3%) , Amenorrhea (2.9%) , Breast Pain (2.3%), , Menstruation Irregular (2.0%) , Lactation Disorder (1.6%).

Known drug interactions: CYP3A4 inhibitors such as indinavir , Anti arrhythmics class IA (e.g., disopyramide, quinidine), anti arrhythmics class III (e.g., amiodarone, dofetilide, dronedarone, ibutilide, sotalol), certain antipsychotics (e.g., haloperidol, pimozide, sertindole), certain antidepressants (e.g., citalopram, escitalopram), certain antibiotics (e.g., levofloxacin, moxifloxacin), certain antifungal agents (e.g., pentamidine), certain antimalarial agents (e.g., halofantrine), certain gastro intestinal drugs (e.g., dolasetron), certain drugs used in cancer (e.g., toremifene, vandetanib), certain other drugs (e.g., bepridil, methadone).

Adults : 10-20mg orally 3-4 times daily before meals , max 80mg daily. Re-evaluate need for continued treatment after 4 week. Children : Nausea & Vomiting - 0.25-0.5mg/kg body-wt , 3-4 times daily, max 2.4mg/kg daily. OR As directed by your physician.

Active ingredient: Domeperidone Maleate.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Domel Pharmaceuticals (Pvt) Ltd.. Country of origin: Turkey.