Cofrest Syrup 120ml

What it is used for: Fever & Cough.

Indications as listed by the manufacturer: Reversible airflow obstruction, Relief of runny nose, Sneezing, Itchy, Watery eyes, Itchy nose, Itchy throat due to hay fever or allergy.

How it works: Theophylline relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels. Ammonium chloride increases acidity by increasing the amount of hydrogen ion concentrations. Ammonium chloride can be used as an expectorant due to its irritative action on the bronchial mucosa. It acts as a counter- irritant by imparting a cooling effect and by initially stimulating nociceptors and then desensitizing them. Diphenhydramine acts as an inverse agonist at the H1 receptor, thereby reversing the effects of histamine on capillaries, reducing allergic reaction symptoms.

Active ingredient: Theophylline , Diphenhydramine , Ammonium Chloride , Menthol.

Reported side effects: Hypersensitivity , Hypokalaemia, hyperglycaemia, electrolyte imbalance , Agitation, restlessness, irritability, nervousness , Headache, insomnia, tremor, convulsions , Heart rate increased, heart rate irregular, palpitations, arrhythmia, ventricular , arrhythmia, tachycardia, sinus tachycardia, supraventricular tachycardia, atrial tachycardia and atria flutter , Hypotension, shock , Nausea, vomiting, diarrhoea, gastrointestinal disorder including gastrointestinal haemorrhage, abdominal pain, haematemesis.

Known drug interactions: Alcohol , Allopurinol , Aminoglutethimide , Barbiturates , Diazepam , Cimetidine , Disulfiram , Erythromycin , Estrogen , Fluvoxamine , Formoterol , Halothane , Imipenem , Isoniazid , Lithium , Macrolides (josamycin,spiramycin) Methotrexate (MTX) , Mexiletine , Moricizine , Pentoxifylline , Phenobarbital , Phenytoin ,Primidone , Propafenone , Propranolol , Rifampin , Sulfinpyrazone , Tacrine , Thiabendazole , Ticlopidine, Troleandomycin , Verapamil , Zileuton.

Adults: 1-2 tsp. Children: 7-12 yr: 1/2 to 1 tsp, 2 to 6 yr: 1/4 to 1/2 tsp or as directed by your physician.

Active ingredient: Theophylline , Diphenhydramine , Ammonium Chloride , Menthol.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Cofrest Pharmaceuticals (Pvt) Ltd.. Country of origin: United Kingdom.