Comox Solution Drops 5ml 1s

What it is used for: Eye Infection.

Indications as listed by the manufacturer: Steroid-responsive inflammatory ocular condition for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists. Post-operative inflammation and any other ocular inflammation associated with infection.

How it works: Moxifloxacin is a synthetic fluoroquinolone antibacterial agent active in vitro against a broad spectrum of Gram-positive and Gram-negative ocular pathogens, atypical microorganisms and anaerobes. The antibacterial action of Moxifloxacin results from inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division. Dexamethasone is a highly potent and long-acting glucocorticoid. The actions of corticosteroids are mediated by the binding of the corticosteroid molecules to receptor molecules located within sensitive cells. Corticosteroids will inhibit phospholipase A2 thereby preventing the generation of substances which mediate inflammation, for example, prostaglandins. Corticosteroids also produce a marked, though transient, lymphocytopaenia. This depletion is due to redistribution of the cells, the T lymphocytes being affected to a greater degree than the B lymphocytes. Lymphokine production is reduced, as is the sensitivity of macrophages to activation by lymphokines. Corticosteroids also retard epithelial regeneration, diminish post-inflammatory neo- vascularisation and reduce towards normal levels the excessive permeability of inflamed capillaries. The actions of corticosteroids described above are exhibited by dexamethasone and they all contribute to its anti-inflammatory effect.

Active ingredient: Moxifloxacin , Dexamethasone Sodium Phosphate.

Reported side effects: Conjunctival irritation , increased lacrimation , keratitis and papillary conjunctivitis, Secondary infection.

Known drug interactions: Atropine and related compounds, phenytoin, phenobarbitone, ephedrine and rifampicin.

Adults : One or two drops instilled into the conjunctival sac every 4 to 6 hr. During initial 24 to 48 hr, the dosage may be increased to 1 or 2 drops every 2hr. Frequency must be decreased gradually or warranted by improvement in clinical signs. Care should be taken not to discontinue the therapy prematurely or as directed by your physician.

Active ingredient: Moxifloxacin , Dexamethasone Sodium Phosphate.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Comox Pharma (Pvt) Ltd.. Country of origin: India.