Flexamine D Tab 20s

What it is used for: Osteoarthritis.

Indications as listed by the manufacturer: It is used as a dietary supplement: - To relieve pain and improve function in patients with mild to moderate osteoarthritis - In joint pain - In cartilage degeneration - In tendonitis - In bursitis .

How it works: Glucosamine : Glucosamine is a normal constituent of polysaccharide chains of cartilage matrix and synovial fluid glucosaminoglycans. It stimulates the synthesis of physiological glycosaminoglycans and proteoglycans by chondrocytes and hyaluronic acid by synoviocytes. Glucosamine Sulfate also inhibits the activity of cartilagedestroying enzymes such as collagenase and phospholipase A2, as well as the generation of other tissue damaging substances such as superoxide radicals or the activity of lysosomal enzymes that contributes to its mild anti-inflammatory effects. Chondroitin Sulfate Sodium : Chondroitin Sulfate increases the synthesis of cartilage matrix components such as hyaluronic acid and proteoglycans and reduces the degradation of cartilage matrix components, specifical ly col lagen II, glycosaminoglycans and proteoglycans, and reduces necrosis and apoptosis of chondrocytes. Chondroitin Sulfate also reduces the activity of collagenase, Nacetylglucosaminidase, aggrecanase 1 and 2, matrix metalloproteinase (MMP) 3, MMP-9, MMP-13, MMP-14, cathepsin B and elastase and elicits an anti-inflammatory effect through diverse mechanisms.

Active ingredient: Glucosamine Sulphate ,Chondroitin Sulphate Sodium.

Reported side effects: Glucosamine: Nausea, diarrhea, epigastric pain/ tenderness, constipation, dyspepsia, indigestion, heartburn, headache, abdominal pain, palpitation, drowsiness, somnolence and skin reactions. Chondroitin Sulfate Sodium: Nausea, diarrhea, mild stomach pain, constipation, swollen eyelids, hair loss, leg swelling, heart burn and irregular heartbeat.

Known drug interactions: Coumarins anticoagulants, blood pressure medicines , NSAIDs, hypoglycemic agents.

Adults : 1 tab/cap/sachet or 10ml syrup three times daily. Children : Not recommended. OR As directed by your physician.

Active ingredient: Glucosamine Sulphate ,Chondroitin Sulphate Sodium.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Flexamine Healthcare (Pvt) Ltd.. Country of origin: Pakistan.