Cortec plus Tablets 2x10s

What it is used for: Hypertension.

Indications as listed by the manufacturer: It is used to treat Hypertension.

How it works: Enalapril maleate : Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE). The mechanism through which enalapril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. In patients treated with enalapril maleate plus a thiazide diuretic, there was essentially no change in serum potassium. Hydrochlorothiazide : Hydrochlorothiazide is a thiazide diuretic. It affects the distal renal tubular mechanism of electrolyte reabsorption. Hydrochlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.

Active ingredient: Enalapril Maleate + Hydrochlorothiazide.

Reported side effects: Headache, depression, fainting • low blood pressure (which may make you feel dizzy when you stand up) • chest pain • heart rhythm changes, fast heart beat • shortness of breath • diarrhoea, pain around your stomach area (abdomen), changes in taste, feeling tired • rash • increased blood potassium level, increases in serum creatinine (both are usually detected by a test) • low levels of potassium in the blood, which can cause muscle weakness, twitching or abnormal heart rhythm, increased levels of cholesterol, increased levels of triglycerides, increased levels of uric acid in the blood • muscle cramps.

Known drug interactions: Sirolimus, everolimus , potassium sparing ‘water tablets’ (diuretics) such as spironolactone, eplerenone, triamterene or amiloride, potassium supplements, or potassium-containing salt substitutes , ‘water tablets’ (diuretics such as thiazides, furosemide, bumetanide), nitroglycerine, nitrates, vasodilators, methyldopa and angiotensin II receptor antagonists (e.g. candesartan, irbesartan and losartan) , lithium , barbiturates , phenothiazines , cholestyramine or colestipol , corticotropin , probenecid, sulfinpyrazone and allopurinol , ciclosporin , procainamide, amiodarone, sotalol, quinidine, hydroquinidine, disopyramide, dofetilide oributilide , digitalis , carbenoxolone , carbamazepine , amphoteracin B .

Adults : Usually 1 or 2 tab once daily. Children : Not Recommended. OR As directed by your physician.

Active ingredient: Enalapril Maleate + Hydrochlorothiazide. Labelled strength: 10mg/25mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Cortec Pharmaceuticals (Pvt) Ltd.. Country of origin: Pakistan.