Cipesta 250mg Tab

What it is used for: Bacterial Infection.

Indications as listed by the manufacturer: It is used to treat : • Lower respiratory tract infections due to Gram-negative bacteria • Acute exacerbation of chronic sinusitis especially if these are caused by Gram-negative bacteria • Urinary tract infections • Genital tract infections

How it works: It acts via inhibition of bacterial DNA gyrase (topoisomerase, which is essential in the reproduction of bacterial DNA), ultimately resulting in interference with DNA function. Ciprofloxacin is highly active against a wide range of Gram-positive and Gram-negative organisms and has shown activity against some anaerobes.

Active ingredient: Ciprofloxacin HCl.

Reported side effects: Nausea, Diarrhoea , Mycotic superinfections, Eosinophilia, Anorexia, Psychomotor hyperactivity / agitation, Headache, Dizziness, Sleep disorders, Taste disorders, Vomiting, Gastrointestinal and abdominal pains, Dyspepsia, Flatulence, Increase in transaminases, Increased bilirubin, Rash, Pruritus, Urticaria, Musculoskeletal pain (e.g. extremity pain, back pain, chest pain), Arthralgia, Renal impairment, Asthenia, Fever, Increase in blood alkaline phosphatase.

Known drug interactions: Theophylline, clozapine, tacrine, ropinirole, tizanidine, duloxetine , Chelation complex formulation like , calcium, magnesium, aluminum or iron), polymeric phosphate binders (e.g., sevelamer), sucralfate or antacids and highly buffered drugs (e.g., didanosine ) , caffeine or pentoxifylline (oxpentifylline) , Phenytoin , Glyburide/Glibenclimide , Warfarin , Probencid , Methotrexate , Metoclopramide , Omeprazole , Cyclosporin , Sildenafil.

Oral : Adults : 250-750mg bid usually for 1-2wk depending on severity and response . Lower RTI : Mild-Moderate : 500mg bid x 1-2wk . Severe 750mg bid or 500mg tid x 1-2wk. Bone Infection : Mild to moderate : 500mg bid x 4-6wk . Severe : 750mg bid x 4-6 wk. Skin Infection : Mild-Moderate : 500mg bid x 4-6 wk . Severe : 750mg bid x 4-6wk. Skin Infection : Mild to moderate : 500mg bid x 4-6wk . Severe : 750mg bid x 1-2 wk . Children : Used only for established following indication and when no other safe alternate available . Acute exacerbation of cystic fibrosis : Under 5 yr, not recommended ; 5-17 yr, 20mg/kg bid x 10-14 days ; max 750mg/dose . Other severe infections : 20mg/kg bid ; max 750mg/dose . Complicated UTI/Pyelonephritis : 1-17yr : 10-20mg/kg bid x 10-21 days . Max : 750mg OR As directed by your physician .

Active ingredient: Ciprofloxacin HCl. Labelled strength: 250mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Cipesta Pharmaceuticals (Pvt) Ltd.. Country of origin: United Kingdom.