Aromasin Tablets 25mg 15s

What it is used for: Cancer.

Indications as listed by the manufacturer: It is an aromatase inhibitor indicated for: Adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to Exemestane for completion of a total of five consecutive years of adjuvant hormonal therapy . Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy .

How it works: Breast cancer cell growth may be estrogen-dependent. Aromatase is the principal enzyme that converts androgens to estrogens both in pre- and postmenopausal women. While the main source of estrogen (primarily estradiol) is the ovary in premenopausal women, the principal source of circulating estrogens in postmenopausal women is from conversion of adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) by the aromatase enzyme in peripheral tissues. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme, causing its inactivation, an effect also known as suicide inhibition. Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on adrenal biosynthesis of corticosteroids or aldosterone. Exemestane has no effect on other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme.

Active ingredient: Exemestane.

Reported side effects: Hot flushes , increased sweating , trouble sleeping , feeling tired , joint pain, headache .

Known drug interactions: Co-medications that induce CYP 3A4 (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital, or St. John's wort) may significantly decrease exposure to exemestane.

The recommended dose of Exemestane in early and advanced breast cancer is one 25 mg tablet once daily after a meal. Or As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Exemestane. Labelled strength: 25mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Aromasin Laboratories (Pvt) Ltd.. Country of origin: Pakistan.