Afert 125mg Tab 10s

What it is used for: Fungal Infection.

Indications as listed by the manufacturer: Terbinafine is used for the treatment of fungal infections of: • The groin area. • The skin (ring worm). • Toe and finger nails (yellow, opaque and thickened nails). • The feet (athlete’s foot).

How it works: Terbinafine is an allylamine which has a broad spectrum of antifungal activity. At low concentrations Terbinafine tablets is fungicidal against dermatophytes, moulds and certain dimorphic fungi. The activity versus yeasts is fungicidal or fungistatic depending on the species. Terbinafine tablets interfere selectively with fungal sterol biosynthesis at an early stage through inhibition of the enzyme squalene epoxidase. This leads to a deficiency in ergosterol and to an intracellular accumulation of squalene in the fungal cell membrane. Both the deficiency in ergosterol and the accumulation of squalene are responsible for fungal cell death.

Active ingredient: Terbinafine HCl.

Reported side effects: Very common (may affect more than 1 in 10 people) • Stomach problems such as loss of appetite, ache, indigestion, feeling bloated or sick • Diarrhoea • Itching, rash or swelling • Pains in the muscles and joints Common (may affect up to 1 in 10 people) • Headache Uncommon (may affect up to 1 in 100 people) • Taste loss and taste disturbance. This usually disappears within several weeks after you stop taking the medicine. However, a very small number of people, (less than 1 in 10,000), have reported that the taste disturbance lasts for some time and, as a result, they go off their food and lose weight. There have also been reports of some people experiencing anxiety or symptoms of depression as a result of these taste disturbances.

Known drug interactions: Rifampicin (an antibiotic). • Cimetidine (used to treat stomach ulcers). • Antidepressants including tricyclic antidepressants, SSRIs (selective serotonin reuptake inhibitors) or MAOIs (monoamine oxidase inhibitors) (medicines for depression). • Oral contraceptives (as irregular periods and breakthrough bleeding may occur in some female patients). • Beta blockers or antiarrhythmics (for heart problems). • Warfarin, a medicine used to thin your blood. • Medicines to treat heart problems (eg propafenone, amiodarone). • Ciclosporin (a medicine used to control your body’s immune system in order to prevent rejection of transplanted organs). • Medicines used to treat fungal infections (e.g. fluconazole, ketoconazole) • Medicines used to treat cough (e.g. dextromethorphan) • Caffeine

The usual dose for adults, including the elderly, is 250 mg once a day. • For skin infections continue taking the tablets for 2 to 6 weeks. • For nail infections treatment usually lasts for between 6 weeks and 3 months, although some patients with toenail infections may need to be treated for 6 months or longer or as directed by your physician.

Active ingredient: Terbinafine HCl. Labelled strength: 125mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Afert Pharmaceuticals (Pvt) Ltd.. Country of origin: Pakistan.