Doris Oral I M Injection 5mgml 1s

What it is used for: Vitamin D Supplement.

Indications as listed by the manufacturer: Prevention of Vitamin D Deficiency due to malabsorption, drugs, certain chronic diseases, disorders of metabolism or other causes. Treatment of vitamin D deficiency states. These include the following: Rickets: In children , Osteomalacia: In adults.

How it works: Cholecalciferol (vitamin D3) is formed in the skin under influence of UV rays and metabolized in two hydroxylation steps at first in the liver and then in the kidney tissue into the biological active metabolite 1,25-dihydroxy-cholecalciferol. 1,25-dihydroxy-cholecalciferol is involved fundamentally in the regulation of the calcium and phosphate balance together with parathyroid hormone and calcitonin.

Active ingredient: Cholecalciferol.

Reported side effects: Acute symptoms : Arrhythmias, nausea, vomiting, psychic symptoms, and impaired consciousnesses. Chronic symptoms : Polyuria, polydipsia, weight loss, kidney stone formation, nephrocalcinosis, extraosseous calcifications

Known drug interactions: Thiazide diuretics , Phenytoin or barbiturates , glucocorticoids

a. Calcium Deficient Rickets: For children > 12months of age: 200,000 IU (1 ampoule) once per month repeated every 3 months until healing is established.b. Osteomalacia: Adults: 100,000 IU (1/2 ampoule) once a week for 6-12 months.c. Vitamin D Deficiency: i. Children > 12 months of age: 100,000 IU (1/2 ampoule) once a month for 3 months, followed by 400-1000 IU/day as maintenance;ii. Adults: 200,000 IU (1 ampoule) once a month for 2-3 months, followed by 100,000 IU (½ ampoule) once a month as maintenance. It is important to obtain calcium, phosphorus, and Alkaline Phosphatase levels before and 1 month after initiating therapy.

Active ingredient: Cholecalciferol. Labelled strength: 200,000Iu.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Doris Pharmaceuticals (Pvt) Ltd.. Country of origin: United Kingdom.