Starcox 90mg Tab 14s

What it is used for: Osteoarthritis.

Indications as listed by the manufacturer: Etoricoxib is indicated for:- Symptomatic relief of osteoarthritis (OA) and rheumatoid arthritis (RA)- The management of ankylosing spondylitis (AS)- Treatment of acute gouty arthritis- Relief of acute pain - Relief of chronic musculoskeletal pain- Treatment of primary dysmenorrhea- Treatment of moderate to severe acute post-operative pain associated with dental surgery- Treatment of moderate to severe acute post-operative pain associated with abdominal gynecological surgery .

How it works: Etoricoxib is an oral, selective cyclo-oxygenase-2 (COX-2) inhibitor. Etoricoxib produced dose-dependent inhibition of COX-2 without inhibition of COX-1 at doses up to 150mg daily. Etoricoxib does not inhibit gastric prostaglandin synthesis and has no effect on platelet function. Selective inhibition of COX-2 by etoricoxib decreases the synthesis of prostanoid mediators of pain, inflammation and fever with decreased potential for GI toxicity and effects on platelet aggregation.

Active ingredient: Etoricoxib.

Reported side effects: Common : Alveolar osteitis, edema/fluid retention, dizziness, headache, palpitations, arrhythmia, hypertension, bronchospasm, constipation, flatulence, gastritis, acid reflux, diarrhea, dyspepsia, epigastric discomfort, nausea, vomiting, ALT increased, AST increased, ecchymosis, asthenia/fatigue and flu-like disease. Uncommon : Gastroenteritis, upper respiratory infection, urinary tract infection, anemia, leukopenia, thrombocytopenia, hypersensitivity, increase or decrease appetite,weight gain, anxiety, depression, mental acuity decreased, hallucinations, dysgeusia, insomnia, paresthaesia/hypaesthesia, somnolence, blurred vision, conjunctivitis, tinnitus, vertigo, atrial fibrillation, tachycardia, congestive heart failure, non-specific ECG changes, angina pectoris, myocardial infarction, flushing, cerebrovascular accident, transient ischemic attack, hypertensive crisis, vasculitis, cough, dyspnea, epistaxis, abdominal distention, bowel movement pattern change, constipation, dry mouth, gastroduodenal ulcer, peptic ulcer, irritable bowel syndrome, pancreatitis, facial edema, pruritus, rash, erythema, urticaria, muscular cramp/spasm, musculoskeletal pain/stiffness,proteinuria, serum creatinine increased, renal failure/renal insufficiency, chest pain, blood urea nitrogen increased, creatine phosphokinase increased, hyperkalemia and uric acid increased. Rare : Angioedema/anaphylactic/anaphylactoid reactions including shock, confusion, restlessness, hepatitis, hepatic failure, jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis, fixed drug eruption and blood sodium decreased.

Known drug interactions: Oral anticoagulants , Diuretics, ACE inhibitors and Angiotensin II antagonists , Acetylsalicylic Acid , Ciclosporin and Tacrolimus , Lithium , Methotrexate , Oral contraceptives , Hormone Replacement Therapy (HRT) , Digoxin , Sulfotransferases , Rifampicin.

Osteoarthritis : The recommended dose is 30mg once daily. In some patients with insufficient relief from symptoms, an increased dose of 60mg once daily may increase efficacy. The dose should not exceed 60mg daily. Rheumatoid Arthritis & Ankylosing Spondylitis : The recommended dose is 60mg once daily. In some patients with insufficient relief from symptoms, an increased dose of 90mg once daily may increase efficacy. Once the patient is clinically stabilised, down-titration to a 60mg once daily dose may be appropriate. The dose should not exceed 90mg daily. Acute Gouty Arthritis : The recommended dose is 120mg once daily. Etoricoxib should not exceed 120mg daily, limited to a maximum of 8 days treatment. Acute Pain : The recommended dose is 120mg once daily. Etoricoxib should be used only for the acute symptomatic period, limited to a maximum of 8 days treatment. Chronic Musculoskeletal Pain : The recommended dose is 60mg once daily. Etoricoxib should be used only for the acute symptomatic period, limited to a maximum of 8 days treatment. Always consult your doctor or pharmacist for dose adjustments.

Active ingredient: Etoricoxib. Labelled strength: 90mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Starcox Pharma (Pvt) Ltd.. Country of origin: Pakistan.