Simbrinza Eye Drops 5ml

What it is used for: Glaucoma.

Indications as listed by the manufacturer: It is used to lower pressure in the eyes in adult patients (aged 18 years and over) who have eye conditions known as glaucoma or ocular hypertension and whose high pressure in the eyes cannot be controlled effectively by one medicine alone.

How it works: It contains two active substances: brinzolamide and brimonidine tartrate. These two components lower intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT) by suppressing the formation of aqueous humour from the ciliary process in the eye. Although both brinzolamide and brimonidine lower IOP by suppressing aqueous humour formation, their mechanisms of action are different. Brinzolamide acts by inhibiting the enzyme carbonic anhydrase (CA-II) in the ciliary epithelium that reduces the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport across the ciliary epithelium, resulting in decreased aqueous humour formation. Brimonidine, an alpha-2 adrenergic agonist, inhibits the enzyme adenylate cyclase and suppresses the cAMP-dependent formation of aqueous humour. Additionally, administration of brimonidine results in an increase in uveoscleral outflow.

Active ingredient: Brinzolamide , Brimonidine tartrate.

Reported side effects: Somnolence , dermatitis , dry throat , hypotension , vertigo , blurred vision , bad taste .

Known drug interactions: MAOIs , oral carbonic anhydrase inhibitors , high-dose salicylate therapy , CNS depressants , antihypertensives/cardiac glycosides , tricyclic antidepressants .

Adults : 1 drop in the affected eye two or three times daily . Children : <2yrs : Not Recommended . OR As directed by your physician.

Active ingredient: Brinzolamide , Brimonidine tartrate.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Simbrinza Pharma (Pvt) Ltd.. Country of origin: Switzerland.