Ruling 40mg Sachet 10s

What it is used for: Gastroesophageal Reflux Disease.

Indications as listed by the manufacturer: It (Omeprazole) is indicated in adults for the treatment of: Gastro-Esophageal Reflux Disease (GERD):- Treatment of erosive reflux esophagitis.- Long term management of patients with healed esophagitis to prevent relapse.- Symptomatic treatment of gastroesophageal reflux disease (GERD).

How it works: Omeprazole reduces gastric acid secretion through a unique mechanism of action. Omeprazole belongs to a class of anti-secretory compounds - the substituted benzimidazoles that do not exhibit anti-cholinergic or H2 histamine antagonistic properties. It inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase (H+/K+ATPase), the proton pump of the gastric parietal cell. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.

Active ingredient: Omeprazole + Sodium Bicarbonte.

Reported side effects: Common : Central and peripheral nervous system: Headache. Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting and flatulence. Uncommon : Central and peripheral nervous system: Dizziness, paraesthesia, somnolence, insomnia and vertigo. Hepatic: Increased liver enzymesSkin: Rash and/or pruritis, urticariaOther: MalaiseRare : Central and peripheral nervous system: Reversible mental confusion, agitation,aggression, depression and hallucinations, predominantly in severely ill patients. Endocrine: Gynecomastia

Known drug interactions: Ketoconazole and itraconazole , diazepam, citalopram, imipramine, clomipramine, phenytoin , Atazanavir , Digoxin , Clopidogrel , posaconazole, erlotinib , Saquinavir , Tacrolimus , Methotrexate , clarithromycin , CYP2C19 or CYP3A4 or both (such as rifampicin and St John's wort.

Short term treatment of active duodenal ulcer : 20mg Once daily for 4 weeks. For Benign gastric ulcer : 40mg Once daily for 4-8 weeks ; Reduction of risk of upper gastrointestinal bleeding in critically ill patients (40mg oral suspension only) : 40mg initially follwed by 40mg 6-8 hours later and 40mg daily thereafter for 14 days . Gastroesophageal Reflux Disease (GERD) : Symptomatic GERD (with no esophageal erosions) : 20mg Once daily for up to 4 weeks , Erosive esophagitis : 20mg Once daily for 4-8 weeks ; Maintenance of healing of erosive esophagitis : 20mg Once daily OR As directed by your physician.

Active ingredient: Omeprazole + Sodium Bicarbonte. Labelled strength: 40mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Ruling Pharmaceuticals (Pvt) Ltd.. Country of origin: United Kingdom.