Ranzol XR 500mg Tablets 14s

What it is used for: Angina.

Indications as listed by the manufacturer: It is indicated for the treatment of chronic angina.

How it works: The mechanism of action of ranolazine is largely unknown. Ranolazine may have some antianginal effects by inhibition of the late sodium current in cardiac cells. This reduces intracellular sodium accumulation and consequently decreases intracellular calcium overload. Ranolazine, via its action to decrease the late sodium current, is considered to reduce these intracellular ionic imbalances during ischaemia. This reduction in cellular calcium overload is expected to improve myocardial relaxation and thereby decrease left ventricular diastolic stiffness. Clinical evidence of inhibition of the late sodium current by ranolazine is provided by a significant shortening of the QTc interval and an improvement in diastolic relaxation in an open-label study of 5 patients with a long QT syndrome (LQT3 having the SCN5A ?KPQ gene mutation).

Active ingredient: Ranolazine.

Reported side effects: Anorexia, decreased appetite, dehydration , hyponatremia , anxiety, insomnia, confusional state, hallucination , disorientation , dizziness, headache , lethargy, syncope, hypoaesthesia, somnolence, tremor, postural dizziness, paresthesia , amnesia, depressed level of consciousness, loss of consciousness, coordination abnormal, gait disturbance, parosmia , myoclonus. Eye disorders , blurred vision, visual disturbance, diplopia , Ear and labyrinth disorders , vertigo, tinnitus , impaired hearing , hot flush, hypotension , peripheral coldness, orthostatic hypotension .

Known drug interactions: Clarithromycin, telithromycin , itraconazole, ketoconazole, voriconazole, posaconazole, protease inhibitors, nefazodone, quinidine, dofetilide, or sotalol , erythromycin , fluconazole , ciclosporin, diltiazem or verapamil , phenytoin, carbamazepine, or phenobarbital, terfenadine, astemizole, mizolastine, disopyramide, procainamide, imipramine, doxepin, amitriptyline, bupropion, psychosis, efavirenz , cyclophosphamide , simvastatin, lovastatin, atorvastatin , tacrolimus, ciclosporin, sirolimus, everolimus .

Adults: The recommended initial dose of Ranolazine is 375 mg twice daily. After 2–4 weeks, the dose should be titrated to 500 mg twice daily and, according to the patient’s response, further titrated to a recommended maximum dose of 750 mg twice daily . Children : Not Recommended. Or As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Ranolazine. Labelled strength: 500mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Ranzol Laboratories (Pvt) Ltd.. Country of origin: United Arab Emirates.