Nixaf 550mg Tab

What it is used for: Bacterial Infection.

Indications as listed by the manufacturer: To reduce the development of drug-resistant bacteria and maintain the effectiveness of Rifaximin and other antibacterial drugs, Rifaximin when used to treat infection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

How it works: Rifaximin acts by binding to the beta-subunit of bacterial DNA dependent RNA polymerase resulting in inhibition of bacterial RNA synthesis. Rifaximin has been shown to be active against the non invasive strain of Escherichia coli (enterotoxigenic and enteroaggregative strains). Rifaximin is believed to affect gut bacteria resulting in a decreased production and/or absorption of bacterial derived neurotoxins, including ammonia, responsible for the neurocognitive and neuromuscular dysfunction seen in patients with Hepatic Encephalopathy.

Active ingredient: Rifaximin.

Reported side effects: Traveler’s Diarrhea : Common : Flatulence, headache, abdominal pain, rectal tenesmus, defecation urgency, nausea, constipation, pyrexia, vomiting. Uncommon : Lymphocytosis, monocytosis, neutropenia, ear pain, motion sickness, tinnitus, abdominal distension, diarrhea, dry throat, fecal abnormality, gingival disorder, inguinal hernia, dry lips, stomach discomfort, chest pain, fatigue, malaise, pain, weakness, dysentery, respiratory tract infection, upper respiratory tract infection, sunburn, aspartate aminotransferase increased, blood in stool, blood in urine, weight decreased, anorexia, dehydration, arthralgia, muscle spasms, myalgia, neck pain, abnormal dreams, dizziness, migraine, syncope, loss of taste, insomnia, choluria, dysuria, hematuria, polyuria, proteinuria, urinary frequency, dyspnea, nasal passage irritation, nasopharyngitis, pharyngitis, pharyngolaryngeal pain, rhinitis, rhinorrhea, clamminess, rash, sweating increased, hot flashes. Hepatic Encephalopathy : Common : Peripheral edema, nausea, dizziness, fatigue, ascites, muscle spasms, pruritus, abdominal pain, abdominal distension, anemia, cough, depression, insomnia, nasopharyngitis, upper abdominal pain, arthralgia, back pain, constipation, dyspnea, pyrexia, rash. Uncommon : Vertigo, lower abdominal pain, abdominal tenderness, dry mouth, esophageal variceal bleed, stomach discomfort, chest pain, generalized edema, influenza like illness, pain, cellulitis, pneumonia, rhinitis, upper respiratory tract infection, confusion, fall, procedural pain, weight increased, anorexia, dehydration, hyperglycemia, hyperkalemia, hypoglycemia, hyponatremia, myalgia, pain in extremity, amnesia, disturbance in attention, hypoesthesia, memory impairment, tremor, confusional state, epistaxis, hypotensi

Known drug interactions: CYP3A4 substrates , rifamycins , substrate of P-glycoprotein.

Rifaximin can be administered with or without food with the following dosage regimen. Traveler's Diarrhea : The recommended dose of Rifaximin is one 200mg tablet taken orally three times a day for 3 days. Hepatic Encephalopathy : The recommended dose of Rifaximin is one 550mg tablet taken orally two times a day. Children : Not Recommended. Always consult your doctor or pharmacist for dose adjustments.

Active ingredient: Rifaximin. Labelled strength: 550mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Nixaf Healthcare (Pvt) Ltd.. Country of origin: United Kingdom.