Drate plus D Tablets 4s

What it is used for: Osteoporosis.

Indications as listed by the manufacturer: It is used in the treatment of post-menopausal osteoporosis to reduce risk of vertebral and hip fractures .

How it works: At the cellular level, alendronate shows preferential localization to sites of bone resorption, specifically under osteoclasts. The osteoclasts adhere normally to the bone surface but lack the ruffled border that is indicative of active resorption. Alendronate does not interfere with osteoclast recruitment or attachment, but it does inhibit osteoclast activity. While incorporated in bone matrix, alendronate is not pharmacologically active. Thus, alendronate must be continuously administered to suppress osteoclasts on newly formed resorption surfaces. Cholecalciferol (vitamin D3) is formed in the skin under influence of UV rays and metabolized in two hydroxylation steps at first in the liver and then in the kidney tissue into the biological active metabolite 1,25-dihydroxy-cholecalciferol. 1,25-dihydroxy-cholecalciferol is involved fundamentally in the regulation of the calcium and phosphate balance together with parathyroid hormone and calcitonin.

Active ingredient: Alendronate Sodium , Cholecalciferol.

Reported side effects: Body as a Whole: Common: Hypersensitivity reactions including urticaria, transient symptoms of myalgia and malaise. Rare: Angioedema, fever, symptomatic hypocalcemia. Gastrointestinal: Common: Esophagitis, esophageal erosions, esophageal ulcers. Rare: Esophageal stricture or perforation and oropharyngeal ulceration. Gastric or duodenal ulcers, some severe and with complications, have also been reported. Skin: Common: Rash (occasionally with photosensitivity), pruritis. Rare: Severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Special Senses: Rare: Uveitis, scleritis.

Known drug interactions: Estrogen/Hormone Replacement Therapy (HRT) , Calcium Supplements/Antacids , Aspirin , Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Treatment of Osteoporosis in Postmenopausal Women : The recommended dosage is: – 1 tablet once weekly . Children : Not recommended . Always consult your doctor or pharmacist for dose adjustments.

Active ingredient: Alendronate Sodium , Cholecalciferol. Labelled strength: 70mg/70mcg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Drate Pharmaceuticals (Pvt) Ltd.. Country of origin: Pakistan.