Calfina plus Tablets 10s

What it is used for: Pain & Inflammation.

Indications as listed by the manufacturer: It is indicated for the treatment of moderate to severe pain.

How it works: Tramadol is a pure, non-selective agonist of the µ, d and k opioid receptors, with a higher affinity for µ receptors. Other mechanisms that contribute to its analgesic effect are inhibition of neuronal reuptake of noradrenaline and enhancement of serotonin release. Tramadol causes an antitussive effect. Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors.

Active ingredient: Tramadol HCl + Paracetamol.

Reported side effects: Very common: may affect more than 1 in 10 people; • Nausea • dizziness, drowsiness Common: may affect up to 1 in 10 people; • Vomiting (being sick), digestion problems (constipation, flatulence, diarrhoea), stomach pain, dry mouth • itching, sweating (hyperhidrosis) • headache, shaking • confusion, sleep disorders, mood changes (anxiety, nervousness, feeling of high spirits). Uncommon: may affect up to 1 in 100 people; • increase in pulse or blood pressure, heart rate or heart rhythm disorders • tingling, numbness or feeling of pins and needles in the limbs, ringing in the ears, involuntary muscle twitching • depression, nightmares, hallucinations (hearing, seeing or sensing things that are not really there), memory lapses • difficulty breathing • difficulty swallowing, blood in the stools.

Known drug interactions: Carbamazepine , Buprenorphine, nalbuphine or pentazocine (opioid-type pain killers) , triptans , SSRIs , morphine , codeine (also as cough medicine), baclofen , benzodiazepines or related drugs , certain antidepressants , warfarin or phenprocoumon (for blood thinning) , Metoclopramide, domperidone and ondansetron , Cholestyramine .

Adults : 1-2 tab three to four times daily. Children : Not recommended. Always consult your doctor or pharmacist for dose adjustments.

Active ingredient: Tramadol HCl + Paracetamol. Labelled strength: 37.5mg/325mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Calfina Healthcare (Pvt) Ltd.. Country of origin: United Kingdom.