Glucophage XR 500mg Tab 30s

What it is used for: Diabetes.

Indications as listed by the manufacturer: Metformin HCl is used to treat patients with type 2 diabetes (also called 'non-insulin dependent diabetes') when diet and exercise alone have not been enough to control your blood glucose levels. It is used particularly in overweight patients.

How it works: Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may actually decrease.

Active ingredient: Metformin HCl.

Reported side effects: Vomiting • Stomach ache (abdominal pain) • Muscle cramps • A general feeling of not being well with severe tiredness • Difficulty in breathing • Reduced body temperature and heartbeat .

Known drug interactions: Alcohol, Iodinated contrast agents , diuretics , corticosteroids , ACE inhibitors , sympathomimetics , NSAIDs , other hypoglycaemics . Inhibitors of OCT2 ( e.g , cimetidine, dolutegravir , ranolazine , trimethoprim ) .

Adults : Initial 500mg twice daily or 850mg daily with meals. Titrate : Increase by 500mg every week, or 850mg every two wk or from 500mg twice daily to 850mg twice daily every 2wk. Max: 2550mg daily. With Insulin : Adults : Initial : 500mg daily. Titrate : 500mg every wk. Max : 2500mg daily. Tab ER,XR ( with or without Insulin ) : Initial 500mg daily with pm meal. Titrate : Increase by 500mg every wk , Max : 2000mg/daily. Children : Monotherapy and in combination with insulin in children above 10yr and adolescent, 500mg twice daily, adjust after 10-15days. Max dose 2gm daily taken as 2 or 3 divided doses. OR As directed by your physician.

Active ingredient: Metformin HCl. Labelled strength: 500mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Glucophage Pharma (Pvt) Ltd.. Country of origin: Pakistan.