Getformin Tablets 2500mg 30s

What it is used for: Diabetes.

Indications as listed by the manufacturer: Glimepiride + Metformin HCl is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes whose diabetes is not adequately controlled with glimepiride or metformin HCl alone, or for those patients who have initially responded to glimepiride or metformin HCl alone and require additional glycemic control.

How it works: Glimepiride: Glimepiride is a third generation sulphonylurea. The primary mechanism of action of glimepiride appears to be dependent on stimulating the release of insulin from functioni ng pancreatic beta cells. In addition, extrapancreatic effects (e.g. reduction of basal hepatic glucose production and increased peripheral tissue sensitivity to insulin and glucose uptake) may also play role in the activity of glimepiride. Metformin HCl: Metformin hydrochloride is a biguanide anti-diabetic, which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its mode of action is thought to be multifactoral and includes delayed uptake of glucose from the intestinal tract, increased peripheral glucose utilization mediated by increased insulin sensitivity and inhibition of increased hepatic and renal gluconeogenesis.

Active ingredient: Glimepiride, Metformin HCl.

Reported side effects: Diarrhea, vomiting, metallic taste, rash, isolated transaminase elevations, cholestatic jaundice, allergic skin reactions, photosensitivity reactions, leukopenia, agranulocytosis, thrombocytopenia, hemolyticanemia, aplastic anemia, pancytopenia and blurred vision. Glimepiride appears to be associated with a low incidence of hypoglycemia.

Known drug interactions: Glimepiride: Salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors , thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics and isoniazid , rifampicin, fluconazole, amiodarone, tolbutamide, diclofenac, ibuprofen, naproxen , clonidine and reserpine. Metformin HCl: Phenprocoumon, hyperglycemic agent (e.g. - thiazides, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channelblocking drugs and isoniazid), alcohol, furosemide, nifedipine and cationic drugs (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim and cimetidine, vancomycin).

Adults : Dosage must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended dose. The maximum daily dose of metformin is 2000mg and of glimepiride is 8mg. The tablets should be swallowed whole and not crushed or chewed. The tablet is tak en once daily with meals to a maximum of 4 tablets/day or as Children : Not recommended OR As directed by the physician.

Active ingredient: Glimepiride, Metformin HCl. Labelled strength: 500mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Getformin Pharma (Pvt) Ltd.. Country of origin: India.