Lochol Ez Tablets 10mg 10mg 10s

What it is used for: Cholesterol Control.

Indications as listed by the manufacturer: It is used to treat : Prevention of Cardiovascular Disease , Primary Hypercholesterolaemia , Homozygous Familial Hypercholesterolaemia (HoFH) .

How it works: Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the rate limiting enzyme responsible for the conversion of 3-hydroxy-3-methyl-glutarylcoenzyme A to mevalonate, a precursor of sterols, including cholesterol. Triglycerides and cholesterol in the liver are incorporated into very low-density lipoproteins (VLDL) and released into the plasma for delivery to peripheral tissues. Low-density lipoprotein (LDL) is formed from VLDL and is catabolized primarily through the receptor with high affinity to LDL (LDL receptor). Atorvastatin reduces total-C, LDL-C and Apo B in both normal volunteers and in patients with homozygous and heterozygous familial hypercholesterolaemia (FH), non-familial forms of hypercholesterolaemia and mixed dyslipidaemia. Atorvastatin also reduces very low density lipoprotein cholesterol (VLDL-C) and triglycerides and produces variable increases in HDL-C and apolipoprotein A-1. Ezetimibe Ezetimibe localizes at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood.

Active ingredient: Atorvastatin , Ezitimibe.

Reported side effects: Common: Diarrhoea and myalgia. Uncommon: influenza, depression, insomnia, sleep disorder, dysgeusia, paraesthesia, dizziness, headache, dyspnoea, sinus bradycardia, hot flush, abdominal discomfort, abdominal pain, abdominal pain lower, abdominal pain upper, frequent bowel movements, stomach discomfort, upset stomach, abdominal distension, constipation, dyspepsia, flatulence, gastritis, nausea, acne, urticaria, arthralgia, back pain, muscle fatigue, muscular weakness, pain in extremity, muscle spasms, musculoskeletal stiffness, asthenia, oedema, fatigue, malaise, ALT and/or AST increased, alkaline phosphatase increased, gamma-glutamyltransferase increased, hepatic enzyme increased, liver function test abnormal, weight increased and blood CK increased.

Known drug interactions: Erythromycin/Clarithromycin , Protease Inhibitors , Itraconazole , Cimetidine , Grapefruit Juice , Colestipol , Cholestyramine , Colchicine , Inhibitors of Breast Cancer Resistance Protein (BCRP) , Ciclosporin , Boceprevir, Anticoagulants , Digoxin , Oral contraceptives.

Dosage in Patients with Primary Hypercholesterolaemia : Atorvastatin + Ezetimibe can be administered within the dosage range of 10mg + 10mg to 80mg + 10mg as a single daily dose. The recommended starting dose of Atorvastatin + Ezetimibe is 10mg + 10mg or 20mg + 10mg once daily . Dosage in Patients with Coronary Heart Disease : The recommended starting dose of Atorvastatin + Ezetimibe in patients already treated with atorvastatin should provide ezetimibe dosed as 10mg daily and the dose of atorvastatin already being taken. Atorvastatin + Ezetimibe is not indicated for first-line use. Dosage in Patients with Homozygous Familial Hypercholesterolaemia (HoFH) : The dosage of Atorvastatin + Ezetimibe in patients with homozygous familial hypercholesterolemia is 10mg + 10mg or 80mg + 10mg daily. Atorvastatin + Ezetimibe should be used as an adjunct to other treatments (e.g., LDL apheresis) in these patients or if such treatments are unavailable. OR As directed by your physician.

Active ingredient: Atorvastatin , Ezitimibe. Labelled strength: 10mg+10mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Lochol Healthcare (Pvt) Ltd.. Country of origin: United Kingdom.