Nebil Tablets 5mg 14s

What it is used for: Hypertension.

Indications as listed by the manufacturer: For the treatment of essential hypertension, stable, mild and moderate chronic heart failure in addition to standard therapies in elderly patients 70 years and may be used alone or in combination with other anti-hypertensive agents.

How it works: Nebivolol is a ß1 selective adrenoceptor antagonist whose hemodynamic effects differ from those of classical ß-adrenoceptor antagonist as a result of a vasodilating action. It has mild vasodilating properties attributed to its interaction with the L-arginine/nitric oxide path way, a property not shared by other ß-blockers. Nebivolol lacks intrinsic sympathomimetic and membrane stabilizing activity at therapeutically relevant concentrations. At clinically relevant doses, nebivolol does not demonstrate a1-adrenergic receptor blockade activity.

Active ingredient: Nebivolol HCl.

Reported side effects: Common: Headache, dizziness, paresthesia, dyspnea, constipation, nausea, diarrhea, tiredness, edema. Uncommon: Nightmares, depression, impaired vision, bradycardia, heart failure, slowed AV conduction/AV-block, hypotension, (increase of) intermittent claudication, bronchospasm, dyspepsia, flatulence, vomiting, pruritus, rash, erythematous, impotence. Rare: Syncope, psoriasis aggravated.

Known drug interactions: Phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes) or antiarrhythmic agents such as disopyramide , digitalis glycosides and ß-blockers , reserpine or guanethidine , clonidine , CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine ) , Cimetidine , Sildenafil.

Hypertension - Adults : The dose is one tablet (5mg) daily, preferably at the same time of the day. Tablets may be taken with or without meals. The initial up titration should be done at 1-2 weekly intervals based on patient tolerability. The maximum recommended dose is 10mg nebivolol once daily . Elderly : In patients over 65 years, the recommended starting dose is 2.5mg daily. If needed, the daily dose may be increased to 5mg. Children : Not recommended. Or As directed by your physician.

Active ingredient: Nebivolol HCl. Labelled strength: 5mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Nebil Pharmaceuticals (Pvt) Ltd.. Country of origin: United Kingdom.