Lefora Tablets 20mg 30s

What it is used for: Rheumatoid Arthritis.

Indications as listed by the manufacturer: It is used to treat adult patients with active rheumatoid arthritis or with active psoriatic arthritis.

How it works: Leflunomide is an immunomodulatory drug that may exert its effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH), which plays a key role in the de novo synthesis of the pyrimidine ribonucleotide uridine monophosphate (rUMP).

Active ingredient: Leflunomide.

Reported side effects: Common side effects (may affect up to 1 in 10 people) : A slight decrease in the number of white blood cells (leucopenia), - mild allergic reactions, - loss of appetite, weight loss (usually insignificant), - tiredness (asthenia), - headache, dizziness, - abnormal skin sensations like tingling (paraesthesia), - mild increase in blood pressure, - colitis, - diarrhoea, - nausea, vomiting, - inflammation of the mouth or mouth ulcers, - abdominal pain. Uncommon side effects (may affect up to 1 in 100 people) : A decrease in the number of red blood cells (anaemia) and a decrease in the number of blood platelets (thrombocytopenia), - a decrease in the levels of potassium in the blood, - anxiety, - taste disturbances, - urticaria (nettle rash), - tendon rupture, - an increase in the levels of fat in the blood (cholesterol and triglycerides), - a decrease in the levels of phosphate in the blood. Rare side effects (may affect up to 1 in 1,000 people) : An increase in the numbers of blood cells called eosinophiles (eosinophilia); mild decrease in the number of white blood cells (leucopenia); decrease in the number of all blood cells (pancytopenia), - severe increase in blood pressure, - inflammation of the lung (interstitial lung disease), - an increase in some liver results which may develop into serious conditions such as hepatitis and jaundice.

Known drug interactions: Chloroquine and hydroxychloroquine, intramuscular or oral gold, D-penicillamine, azathioprine and other immunosuppressive medicines (e.g. methotrexate ) , warfarin , teriflunomide , repaglinide, pioglitazone, nateglinide, or rosiglitazone , daunorubicin, doxorubicin, paclitaxel, or topotecan , duloxetine , alosetron , theophylline , tizanidine , oral contraceptives (containing ethinylestradiol and levonorgestrel) , cefaclor, benzylpenicillin , indomethacin, ketoprofen , furosemide , zidovudine , rosuvastatin, simvastatin, atorvastatin, pravastatin , sulfasalazine.

The usual starting dose of Leflunomide is one 100 mg tablet once daily for the first three days. After this, most patients need a dose of: • For Rheumatoid Arthritis: 10 or 20 mg Leflunomide once daily, depending on the severity of the disease. • For Psoriatic Arthritis: 20 mg Leflunomide once daily. Children : Not recommended. Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Active ingredient: Leflunomide. Labelled strength: 20mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Lefora Healthcare (Pvt) Ltd.. Country of origin: Turkey.