Lefora Tablets 10mg 30s

What it is used for: Rheumatoid Arthritis.

Indications as listed by the manufacturer: It is used to treat adult patients with active rheumatoid arthritis or with active psoriatic arthritis.

How it works: Leflunomide is an immunomodulatory drug that may exert its effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH), which plays a key role in the de novo synthesis of the pyrimidine ribonucleotide uridine monophosphate (rUMP).

Active ingredient: Leflunomide.

Reported side effects: Common side effects (may affect up to 1 in 10 people) : A slight decrease in the number of white blood cells (leucopenia), - mild allergic reactions, - loss of appetite, weight loss (usually insignificant), - tiredness (asthenia), - headache, dizziness, - abnormal skin sensations like tingling (paraesthesia), - mild increase in blood pressure, - colitis, - diarrhoea, - nausea, vomiting, - inflammation of the mouth or mouth ulcers, - abdominal pain. Uncommon side effects (may affect up to 1 in 100 people) : A decrease in the number of red blood cells (anaemia) and a decrease in the number of blood platelets (thrombocytopenia), - a decrease in the levels of potassium in the blood, - anxiety, - taste disturbances, - urticaria (nettle rash), - tendon rupture, - an increase in the levels of fat in the blood (cholesterol and triglycerides), - a decrease in the levels of phosphate in the blood. Rare side effects (may affect up to 1 in 1,000 people) : An increase in the numbers of blood cells called eosinophiles (eosinophilia); mild decrease in the number of white blood cells (leucopenia); decrease in the number of all blood cells (pancytopenia), - severe increase in blood pressure, - inflammation of the lung (interstitial lung disease), - an increase in some liver results which may develop into serious conditions such as hepatitis and jaundice.

Known drug interactions: Chloroquine and hydroxychloroquine, intramuscular or oral gold, D-penicillamine, azathioprine and other immunosuppressive medicines (e.g. methotrexate ) , warfarin , teriflunomide , repaglinide, pioglitazone, nateglinide, or rosiglitazone , daunorubicin, doxorubicin, paclitaxel, or topotecan , duloxetine , alosetron , theophylline , tizanidine , oral contraceptives (containing ethinylestradiol and levonorgestrel) , cefaclor, benzylpenicillin , indomethacin, ketoprofen , furosemide , zidovudine , rosuvastatin, simvastatin, atorvastatin, pravastatin , sulfasalazine.

The usual starting dose of Leflunomide is one 100 mg tablet once daily for the first three days. After this, most patients need a dose of: • For Rheumatoid Arthritis: 10 or 20 mg Leflunomide once daily, depending on the severity of the disease. • For Psoriatic Arthritis: 20 mg Leflunomide once daily. Children : Not recommended. Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Leflunomide. Labelled strength: 10mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Lefora Pharma (Pvt) Ltd.. Country of origin: India.