Ivirem 100mg Inj 1s Injection

What it is used for: Viral Infection.

Indications as listed by the manufacturer: It is used for the treatment of coronavirus disease 2019 (COVID-19) in adults and children 12 years of age and older and weighing at least 88 pounds (40 kg) who are: • Hospitalized, or • Not hospitalized and have mild-to-moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death.

How it works: Remdesivir is an adenosine nucleotide prodrug that distributes into cells where it is metabolized to form the pharmacologically active nucleoside triphosphate metabolite. Metabolism of remdesivir to remdesivir triphosphate has been demonstrated in multiple cell types. Remdesivir triphosphate acts as an analog of adenosine triphosphate (ATP) and competes with the natural ATP substrate for incorporation into nascent RNA chains by the SARS-CoV-2 RNA-dependent RNA polymerase, which results in delayed chain termination during replication of the viral RNA. Remdesivir triphosphate is a weak inhibitor of mammalian DNA and RNA polymerases with low potential for mitochondrial toxicity .

Active ingredient: Remdesivir.

Reported side effects: Allergic reactions : Changes in your heart rate , rash , fever , nausea , shortness of breath, wheezing , sweating , swelling of the lips, face, or throat , shivering • Increase in liver enzymes : Increases in liver enzymes are common in people who have received Remdesivir and may be a sign of liver injury .

Known drug interactions: Ask your physician or pharmacist for any drug interaction.

Adults and Paediatric Patients above 40 kg : The recommended dosage in adults and Paediatric Patients above 40 kg is a single loading dose of remdesivir 200 mg infused intravenously over 30 to 120 minutes on Day 1 followed by once-daily maintenance doses of remdesivir 100 mg infused intravenously over 30 to 120 minutes for 4 days. Paediatric patients with body weight between 3.5kg and less than 40 kg : The recommended dosage in paediatric patients with body weight between 3.5kg and less than 40kg should be single loading dose of 5mg/kg IV infused over 30-120 minutes on day 1 followed by 2.5mg/kg IV infused over 30-120 minutes once daily for 4 days. OR As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Remdesivir. Labelled strength: 100mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Ivirem Pharma (Pvt) Ltd.. Country of origin: United Arab Emirates.