Inograf 1mg 3x10 Capsules

What it is used for: Immunosuppresant.

Indications as listed by the manufacturer: Tacrolimus is a calcineurin-inhibitor immunosuppressant indicated for : Prophylaxis of organ rejection in patients receiving allogeneic liver, kidney or heart transplants .

How it works: Tacrolimus belongs to a group of medicines called immunosuppressants. Following your organ transplant (e.g. liver, kidney, heart), your body’s immune system will try to reject the new organ. Tacrolimus is used to control your body’s immune response enabling your body to accept the transplanted organ. Tacrolimus is often used in combination with other medicines that also suppress the immune system.

Active ingredient: Tacrolimus.

Reported side effects: Serious common side effects (may affect up to 1 in 10 people): Gastrointestinal perforation: strong abdominal pain accompanied or not with other symptoms, such as chills, fever, nausea or vomiting , Insufficient function of your transplanted organ , Blurred vision. Serious uncommon side effects (may affect up to 1 in 100 people): Haemolytic uraemic syndrome, a condition with the following symptoms: low or no urine output (acute renal failure), extreme tiredness, yellowing of the skin or eyes (jaundice) and abnormal bruising or bleeding and signs of infection. Serious rare side effects (may affect up to 1 in 1,000 people): Thrombotic Thrombocytopenic Purpura (or TTP) a condition characterised by fever and bruising under the skin that may appear as red pinpoint dots, with or without unexplained extreme tiredness, confusion, yellowing of the skin or eyes (jaundice), with symptoms of acute renal failure (low or no urine output).

Known drug interactions: St John's Wort (hypericum perforatum), a herbal preparation which is capable of decreasing tacrolimus blood levels • antifungal agents such as ketoconazole, fluconazole, itraconazole, voriconazole • erythromycin (macrolide antibiotic) • HIV protease inhibitors (e.g. ritonavir) • clotrimazole • clarithromycin • josamycin • nifedipine • nicardipine • diltiazem • verapamil • danazol • ethinylestradiol • omeprazole • nefazodone • rifampicin • phenytoin • cyclosporin • steroid-based contraceptives • potassium sparing diuretics (e.g. amiloride, triamterene or spironolactone) • live attenuated vaccines.

Adults : Oral liver transplantation : 0.1-0.2mg/kg/day in 2 divided doses , start approx 6 hr after completion of surgery. Kidney transplantation : 0.15-0.3mg/kg/day in 2 divided doses , start within 24 hr of surgery. Children : Oral liver transplantation : 0.3mg/kg/day in 2 divided doses. Always consult your doctor or pharmacist for dose adjustments.

Active ingredient: Tacrolimus. Labelled strength: 1mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Inograf Laboratories (Pvt) Ltd.. Country of origin: Switzerland.