Hyzonate Injection 100mg

What it is used for: Pain & Inflammation.

Indications as listed by the manufacturer: It is used to treat shock following surgery, injuries, hypersensitivity (anaphylactic) reactions or other stressful conditions.

How it works: Hydrocortisone sodium succinate has the same metabolic and anti-inflammatory actions as hydrocortisone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity. The highly water-soluble sodium succinate ester of hydrocortisone permits the immediate intravenous administration of high doses of hydrocortisone in a small volume of diluent and is particularly useful where high blood levels of hydrocortisone are required rapidly. Following the intravenous injection of hydrocortisone sodium succinate, demonstrable effects are evident within one hour and persist for a variable period.

Active ingredient: Hydrocortisone sodium succinate.

Reported side effects: Allergic reactions, such as skin rash, swelling of the face or wheezing and difficulty breathing. This type of side effect is rare, but can be serious. • Acute pancreatitis, stomach pain which may spread through to your back, possibly accompanied by vomiting, shock and loss of consciousness. • Ulcers or bleeding ulcers, symptoms of which are severe stomach pain which may go through to the back and could be associated with bleeding from the back passage, black or bloodstained stools and/or vomiting blood • Pulmonary embolus (blood clot in the lung) symptoms include sudden sharp chest pain, breathlessness and coughing up blood. • Raised pressure within the skull of children (pseudotumour cerebri) symptoms of which are headaches with vomiting, lack of energy and drowsiness. This side effect usually occurs after treatment is stopped. • Thrombophlebitis (blood clots or thrombosis in a leg vein), symptoms of which include painful swollen, red and tender veins.

Known drug interactions: Acetazolamide , Aminoglutethimide , Anticoagulants , Anticholinergics , Anticholinesterases , Antibiotics , Antidiabetics , Antiemetic , Aspirin , Barbiturates, carbamazepine, phenytoin and primidone , Carbenoxolone and cimetidine , Ciclosporin , Digoxin , Diltiazem or mibefradil , Diuretics , Isoniazid , Antivirals (such as ritonavir, indinavir) , Ethinylestradiol / Norethindrone , Ketoconazole or itraconazole , Pancuronium , Rifampicin and rifabutin , Tacrolimus and cyclophosphamide , Vaccines , Grapefruit juice

Dose should be based on severity of disease and patient response. Adults : Anyi-inflammatory or immunosuppressive : Oral/IM/IV : 15-240mg every 12hr. Adrenal insufficiency : Oral : 100mg IV bolus , then 300mg/day in divided doses every 8hr or as a continuous infusion for 48hr; once patient is stable change to oral, 50mg every 8hr for 6 doses, then taper to 30-50mg/day in divided doses. Children : Inflammatory bowel disease , induction of remission : IV injection : 2-18yr, 2.5mg/kg (max 100mg) every 6hr. IV infusion : 2-18yr , 10mg/kg daily (max 400mg daily ). Acute hypersensitivity reactions, angioedema : IM or IV injection . Under 6mnth, initially 25mg 3 times daily, adjusted according to response ; 6mnth-6yr, initially 50mg 3 times daily, adjusted according to response ; 6-12yr, initially 100mg 3 times daily, adjusted according to response; 12-18yr, initially 200mg 3 times daily, adjusted according to response. OR As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Hydrocortisone sodium succinate. Labelled strength: 100mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Hyzonate Healthcare (Pvt) Ltd.. Country of origin: Pakistan.