Hydralazine Hcl 25mg 2x10s

What it is used for: Hypertension.

Indications as listed by the manufacturer: Hydralazine used to: • Treat moderate to severe high blood pressure (with or without a betablocker or diuretic medicine) • Manage moderate to severe congestive heart failure (where use of other medicines alone is not enough).

How it works: Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. Hydralazine, by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state. The peripheral vasodilating effect of hydralazine results in decreased arterial blood pressure (diastolic more than systolic); decreased peripheral vascular resistance; and an increased heart rate, stroke volume, and cardiac output. The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output. Hydralazine usually increases renin activity in plasma, presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption. Hydralazine also maintains or increases renal and cerebral blood flow.

Active ingredient: Hydralazine HCl.

Reported side effects: Common: Headache, anorexia, nausea, vomiting, diarrhea, palpitations, tachycardia, angina pectoris. Less Frequent: Digestive: constipation, paralytic ileus. Cardiovascular: hypotension, paradoxical pressor response, edema. Respiratory: dyspnea. Neurologic: peripheral neuritis, evidenced by paresthesia, numbness, and tingling; dizziness; tremors; muscle cramps; psychotic reactions characterized by depression, disorientation, or anxiety. Genitourinary: difficulty in urination. Hematologic: blood dyscrasias, consisting of reduction in hemoglobin and red cell count, leukopenia, agranulocytosis, purpura; lymphadenopathy; splenomegaly. Hypersensitive Reactions: rash, urticaria, pruritus, fever, chills, arthralgia, eosinophilia, and, rarely, hepatitis. Other: nasal congestion, flushing, lacrimation, conjunctivitis.

Known drug interactions: MAO inhibitors , antihypertensive drugs, such as diazoxide .

Adults : Hypertension : 25mg twice daily, increased to usual max 50mg twice daily. Heart failure : ( Initiated in hospital ) 25mg 3-4 times daily, increased every 2 days if necessary; usual maintenance dose 50-75mg 4 times daily. Children : Not recommended . OR As directed by your physician.

Active ingredient: Hydralazine HCl. Labelled strength: 25mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Hydralazine Healthcare (Pvt) Ltd.. Country of origin: United Kingdom.