Ramipace Tablets 10mg 28s

What it is used for: Hypertension.

Indications as listed by the manufacturer: It is used: • To treat high blood pressure (hypertension) • To reduce the risk of you having a heart attack or stroke.

How it works: Ramiprilat, the active metabolite of the prodrug ramipril, inhibits the enzyme dipeptidylcarboxypeptidase I (synonyms: angiotensin-converting enzyme; kininase II). In plasma and tissue this enzyme catalyses the conversion of angiotensin I to the active vasoconstrictor substance angiotensin II, as well as the breakdown of the active vasodilator bradykinin. Reduced angiotensin II formation and inhibition of bradykinin breakdown lead to vasodilatation.

Active ingredient: Ramipril.

Reported side effects: Common (may affect up to 1 in 10 people) • Headache or feeling tired • Feeling dizzy. This is more likely to happen when you start taking ramipril or start taking a higher dose • Fainting, hypotension (abnormally low blood pressure), especially when you stand or sit up quickly • Dry tickly cough, inflammation of your sinuses (sinusitis) or bronchitis, shortness of breath • Stomach or gut pain, diarrhoea, indigestion, feeling or being sick • Skin rash with or without raised area • Chest pain • Cramps or pain in your muscles • Blood tests showing more potassium than usual in your blood. Uncommon (may affect up to 1 in 100 people) • Balance problems (vertigo) • Itching and unusual skin sensations such as numbness, tingling, pricking, burning or creeping on your skin (paraesthesia) • Loss or change in the way things taste • Sleep problems • Feeling depressed, anxious, more nervous than usual or restless • Blocked nose, difficulty breathing or worsening of asthma .

Known drug interactions: Sacubitril/valsartan , (NSAIDs) such as ibuprofen or indometacin and aspirin) , ciclosporin , furosemide , triamterene, amiloride, potassium salts, trimethoprim alone or in combination with sulfamethoxazole , Allopurinol , Procainamide , Temsirolimus , Sirolimus, everolimus , Vildagliptin , Racecadotril .

Treatment of high blood pressure • The usual starting dose is 1.25 mg or 2.5 mg once daily. • Your doctor will adjust the amount you take until your blood pressure is controlled. • The maximum dose is 10 mg once daily. • If you are already taking diuretics (water tablets), your doctor may stop or reduce the amount of the diuretic you take before beginning treatment with Ramipril. To reduce the risk of you having a heart attack or stroke : • The usual starting dose is 2.5 mg once daily. • Your doctor may then decide to increase the amount you take. • The usual dose is 10 mg once daily. Always consult your doctor or pharmacist for dose adjustments.

Active ingredient: Ramipril. Labelled strength: 10mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Ramipace Laboratories (Pvt) Ltd.. Country of origin: Pakistan.