Fluderm Capsules 50mg 10s

What it is used for: Fungal Infection.

Indications as listed by the manufacturer: It is used to treat infections caused by fungi and may also be used to stop you from getting a candidal infection. The most common cause of fungal infections is a yeast called Candida.

How it works: Fluconazole is a triazole antifungal agent. Its primary mode of action is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell membrane and may be responsible for the antifungal activity of fluconazole. Fluconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems.

Active ingredient: Fluconazole.

Reported side effects: Common side effects (may affect up to 1 in 10 people) are: - Headache - stomach discomfort, diarrhoea, feeling sick, vomiting - increases in blood tests of liver function - rash . Uncommon side effects (may affect up to 1 in 100 people) are: - Reduction in red blood cells which can make skin pale and cause weakness or breathlessness - decreased appetite- inability to sleep, feeling drowsy - fit, dizziness, sensation of spinning, tingling, pricking or numbness, changes in sense of taste - constipation, difficult digestion, wind, dry mouth - muscle pain - liver damage and yellowing of the skin and eyes (jaundice) - wheals, blistering (hives), itching, increased sweating - tiredness, general feeling of being unwell, fever.

Known drug interactions: Rifampicin or rifabutin- alfentanil, fentanyl - amitriptyline, nortriptyline - amphotericin B, voriconazole - warfarin or similar medicines - benzodiazepines (midazolam, triazolam or similar medicines) - carbamazepine, phenytoin - nifedipine, isradipine, amlodipine, verapamil, felodipine and losartan (for hypertension- olaparib - ciclosporin, everolimus, sirolimus or tacrolimus - cyclophosphamide, vinca alkaloids (vincristine, vinblastine or similar medicines)- halofantrine- statins (atorvastatin, simvastatin and fluvastatin or similar medicines) - methadone - celecoxib, flurbiprofen, naproxen, ibuprofen, lornoxicam, meloxicam, diclofenac (NonSteroidal Anti-Inflammatory Drugs (NSAID)) - oral contraceptives - prednisone (steroid) - zidovudine, also known as AZT; saquinavir (used in HIV-infected patients) -chlorpropamide, glibenclamide, glipizide or tolbutamide - theophylline - tofacitinib - tolvaptan used to treat hyponatremia- vitamin A (nutritional supplement) - ivacaftor - amiodarone - hydrochlorothiazide (a diuretic) - ibrutinib .

Vaginal candidiasis and candidal balanitis : Adults : Orally, a single dose of 150mg. Mucosal candidiasis ( except genital ) : Adults : Orally, 50mg daily ( 100mg daily in unusually difficult infections ) given for 7-14 days in oropharyngeal candidiasis ( max 14 days except in severely immunocompromised patients ) ; for 14 days in atrophic oral candidiasis associated with dentures for 14-30 days in other mucosal infections ( e.g. oesophagitis, candiduria , non-invasive bronchopulmonary infections). Children : Orally or by IV infusion , 3-6mg/kg on first day then 3mg/kg daily ( every 72 hr in neonates upto 2wk old , every 48hr in neonates of 2-4 wk old ). OR As as directed by your physician.

Active ingredient: Fluconazole. Labelled strength: 50mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Fluderm Healthcare (Pvt) Ltd.. Country of origin: United Kingdom.