Fenoget Capsules 67mg 30s

What it is used for: Cholesterol Control.

Indications as listed by the manufacturer: Fenofibrate is indicated as adjunctive therapy to diet to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (Total-C), triglycerides (TG), and apolipoprotein B (Apo B), and to increase high-density lipoprotein cholesterol (HDL-C) in adult patients with primary hyperlipidemia or mixed dyslipidemia.

How it works: Fenofibrate is a fibric acid derivative whose lipid modifying effects reported in humans are mediated via activation of Peroxisome Proliferator Activated Receptor type alpha (PPARa). Through activation of PPARa, fenofibrate increases the lipolysis and elimination of atherogenic triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein CIII. Activation ofPPARa also induces an increase in the synthesis of apoproteins AI and AII. The above stated effects of fenofibrate on lipoproteins lead to a reduction in very low and low density fractions (VLDL and LDL) containing apoprotein B and an increase in the high density lipoprotein fraction (HDL) containing apoprotein AI and AII. In addition, through modulation of the synthesis and the catabolism of VLDL fractions fenofibrate increases the LDL clearance and reduces small dense LDL, the levels of which are elevated in the atherogenic lipoprotein phenotype, a common disorder in patients at risk for coronary heart disease.

Active ingredient: Fenofibrate.

Reported side effects: Common: Abdominal pain, nausea, vomiting, diarrhea, flatulence and transaminases increased. Uncommon: Headache, pulmonary embolism, deep vein thrombosis, pancreatitis, cholelithiasis, cutaneous hypersensitivity (e.g. rashes, pruritus, urticaria) and muscle disorder (e.g. myalgia, myositis, muscular spasms and weakness). Rare: Hemoglobin decreased, white blood cell count decreased, hypersensitivity,hepatitis, alopecia and photosensitivity reactions .

Known drug interactions: Oral Anticoagulants , HMG-CoA Reductase Inhibitors (Statins) , Resins , Cyclosporine , Beta-blockers, thiazides, estrogens , Daptomycin , Antidiabetics , Colchicine .

Primary Hypercholesterolemia or Mixed Dyslipidemia : The initial dose of Fenofibrate capsules is 200mg per day. Hypertriglyceridemia For adult patients with hypertriglyceridemia, the initial dose is 67mg to 200mg per day. Dosage should be individualized according to patient response, and should be adjusted if necessary following repeat lipid determinations at 4 to 8 week intervals. The maximum dose is 200mg per day or As directed by your physician.

Active ingredient: Fenofibrate. Labelled strength: 67mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Fenoget Laboratories (Pvt) Ltd.. Country of origin: Switzerland.