Noclot Tablets 75mg 20s

What it is used for: Stroke.

Indications as listed by the manufacturer: Secondary prevention of atherothrombotic events : Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months) or establishedperipheral arterial disease. Prevention of atherothrombotic and thromboembolic events in atrial fibrillation: In adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with Vitamin K antagonists (VKA) and who have a low bleeding risk, clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke.

How it works: Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation. Clopidogrel must be metabolised by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation. The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Due to the irreversible binding, platelets exposed are affected for the remainder of their lifespan (approximately 7-10 days) and recovery of normal platelet function occurs at a rate consistent with platelet turnover. Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP.

Active ingredient: Clopidogrel.

Reported side effects: Abdominal pain, dyspepsia, gastritis, diarrhea, nausea, vomiting, constipation, gastrointestinal hemorrhage, ulceration, neutropenia, rash, palpitation, syncope, drowsiness, asthenia, neuralgia, paresthesia and vertigo.

Known drug interactions: Warfarin , Glycoprotein IIb/IIIa inhibitors , Acetylsalicylic acid (ASA) , Heparin , Thrombolytics , NSAIDs , SSRIs , omeprazole and esomeprazole, fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, carbamazepine, and efavirenz .

Adults : 75mg daily with or without food. Non-ST segment elevation acute coronary syndrome : Adults - 300mg loading dose followed by 75mg daily given in combination with 75-100mg aspirin daily. Children : Not recommended. Always consult your doctor or pharmacist for dose adjustments.

Active ingredient: Clopidogrel. Labelled strength: 75mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Noclot Laboratories (Pvt) Ltd.. Country of origin: United Arab Emirates.