Estezene 5mg Tablets 100s

What it is used for: Schizophrenia.

Indications as listed by the manufacturer: At a low dose, it is used to manage anxiety and depression. It is used in this way for short periods of time . • It may also be used to treat nausea (feeling sick) and vomiting (being sick). • At high doses, it is used to treat and prevent relapses of schizophrenia (a serious mental illness) and related conditions.

How it works: A piperazine, phenothiazine tranquiliser with potent anti-psychotic, anxiolytic and antiemetic activity, and a pharmacological profile of moderate sedative and hypotensive properties and fairly pronounced tendency to cause extra pyramidal reactions.

Active ingredient: Trifluoperazine HCl.

Reported side effects: Leucopenia , thrombocytopenia , hyperprolactinaemia , acute dystonias and dyskinesias , Parkinsonism , drowsiness , insomnia , tachycardia , hypotension , erythemas , anticholinergic effects , anorexia , depression , rash , photosensitivity , convulsions , blood dyscrasias , extrapyramidal symptoms , agitation , mental dulness , dizziness , ECG changes . Rarely , agranulocytosis , jaundice , neuroleptic malignant syndrome .

Known drug interactions: Strong pain killers (e.g. codeine) • Medicines which result in lowering of blood pressure (e.g. guanethidine) • Anticholinergic medicines used to reduce saliva and lung secretions (e.g. atropine, procyclidine) • Antidepressants (e.g. other phenothiazines, lithium) • Medicines for fits (anticonvulsants) • Medicines for Parkinson’s disease (e.g. levodopa) • Blood thinning medicines (anticoagulants such as warfarin) • Medicines used to treat iron poisoning (desferrioxamine) • Antacids used to treat indigestion • Medicines for psychiatric conditions (neuroleptics) • Heart medicines which prolong the QT interval (e.g quinidine, disopyramide, procainamide, amiodarone, sotalol) • Drugs causing electrolyte imbalances (e.g diuretics) .

Schizophrenia : Low dose : 1-2 mg orally every 12 hour. High Dose : Initial: 2-5 mg orally every 12 hour ; Maintenance Dose: 15-20 mg/day . Not to exceed 40mg/day . Non Psychotic Anxiety : 1-2 mg orally every 12 hour . Maximum Dose: 6 mg/day; not to exceed 12 weeks. Renal Impairment : Dose adjustment not necessary following dialysis or as directed by your physician.

Active ingredient: Trifluoperazine HCl. Labelled strength: 5mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Estezene Healthcare (Pvt) Ltd.. Country of origin: Germany.