Enoxabid Tablets 400mg 2x10s

What it is used for: Bacterial Infection.

Indications as listed by the manufacturer: It is indicated in the following infections caused by susceptible organisms:Upper Respiratory Tract / ENT: Pharyngitis, peritonsillar abscess, otitis media, sinusitis. Lower Respiratory Tract: Acute bronchitis, acute exacerbations of chronic bronchitis, bronchiectasis with infection, pneumonia and lung abscess. Skin/Skin Structures: Folliculitis, furunculosis, carbuncles, impetigo, cellulitis, secondary infections of wounds, burns and surgical incisions. Urinary Tract: Acute/simple and chronic/complicated urinary tract infections, including cystitis, pyelonephritis and prostatitis. Sexually Transmitted Diseases: Gonococcal urethritis. GI Tract: Bacillary dysentery and enteritis, Typhoid (enteric fever)

How it works: Enoxacin blocks DNA synthesis during bacterial replication by inhibiting the bacterial enzyme DNA gyrase. It has a broad antibacterial spectrum against Gram-positive and Gram-negative bacteria at bioavailable concentrations achievable in body tissues and fluids.

Active ingredient: Enoxacin Sesquihydrate.

Reported side effects: Renal: Acute renal failure may rarely occur and transient elevation in BUN and serum creatinine levels have been occasionally observed. Hematologic: Transient increases in eosinophil counts and decreases in leucocyte counts, thrombocyte counts and hemoglobin levels may infrequently occur. If any such abnormalities are observed, adminstration should be discontinued. Gastrointestinal: Nausea, vomiting, anorexia, abdominal pain, discomfort, diarrhoea, constipation may infrequently occur and stomatitis may rarely occur. Severe colitis associated with bloody stool, such as pseudomembranous colitis, has also been reported with the use of other new quinolones, If abdominal pain or frequent diarrhoea develops the drug must be discontinued and appropriate measures taken. Elevation of SGOT, SGPT, and ALP, may infrequently occur and increase of bilirubin may rarely occur. Central Nervous System: Dizziness, headache and insomnia may infrequently occur and convulsions, drowsiness, feeling of numbness, tinnitus, light headache feeling, tremor or dull headache may rarely occur. Peripheral neuropathy that may be irreversible Muscular: Rhabdomyolysis occurring with acute renal function disorder, characterized by myalgias, weakness, elevation of CPK, and elevation of plasma/urine myoglobin level, may occur. Therefore, appropriate precautions should be taken. Skin: Since Lyell syndrome and Stevens Johnson syndrome may occur rarely, the patient must be monitored carefully. Administration of Enoxacin must be discontinued when any abnormality is observed and the patient should be treated appropriately. Others: Palpitation, precordial discomfort, malaise, hypoglycemic symptoms, diminished taste or backache may rarely occur.

Known drug interactions: Concurrent use of Enoxacin with theophylline has been reported to enhance the effects of theophylline by elevating its serum level. Therefore, the dosage of theophylline should be reduced during concurrent therapy. There is a possibility of convulsive episodes caused by the concomitant use of Enoxacin with non-steroidal anti-inflammatory analgesics of the phenylacetic acid or propionic acid group (e.g. fenbufen and, therefore, co-administration should be done carefully. Concurrent administration of antacids containing magnesium hydoroxide or aluminum hydroxide may interfere with the absorption of Enoxacin resulting in serum levels lower than desired for therapy against some organisms.

For the treatment of acute and chronic infections, the usual daily dosage is 400 mg to 800 mg administered in two divided doses for up to 7-14 days or longer, depending on the severity response of the infection. For the treatment of typhoid fever 400 mg. twice daily for 10-14 days. For the treatment of gonococccal urethritis, the recommended dosage is 400 mg as a single dose. In patients with severe impairment of renal function, the dosage must be adjusted either by dividing the normally recommended dose by two or by multiplying the interval between doses (in hours) by two. OR As directed by your physician.

Active ingredient: Enoxacin Sesquihydrate. Labelled strength: 400mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Enoxabid Laboratories (Pvt) Ltd.. Country of origin: Pakistan.