Eloxitan 50mg Injection

What it is used for: Cancer.

Indications as listed by the manufacturer: It is used to treat cancer of the large bowel (treatment of stage III colon cancer after complete resection of primary tumour, metastatic cancer of colon and rectum).

How it works: Oxaliplatin is an antineoplastic active substance belonging to a new class of platinum-based compounds in which the platinum atom is complexed with 1,2-diaminocyclohexane (“DACH”) and an oxalate group. Oxaliplatin exhibits a wide spectrum of both in vitro cytotoxicity and in vivo antitumour activity in a variety of tumour model systems including human colorectal cancer models. Oxaliplatin also demonstrates in vitro and in vivo activity in various cisplatin resistant models.

Active ingredient: Oxaliplatin.

Reported side effects: Very common (may affect more than 1 in 10 people) : Allergies/allergic reactions, occurring mainly during infusion, sometimes fatal - Stomatitis / mucositis (sore lips or mouth ulcers) - Low platelet count, abnormal bruising (thrombocytopenia). Your doctor will take blood to check that you have sufficient blood cells before you start treatment and before each subsequent course. - Unexplained respiratory symptoms such as dry cough, difficulties in breathing or crackles. Common (may affect up to 1 in 10 people) : Serious infection of the blood in addition to a reduction in white blood cells (neutropenic sepsis), which may be fatal - Reduction in white blood cells accompanied by fever > 38.3°C or a prolonged fever > 38°C for more than one hour (febrile neutropenia) - Symptoms of an allergic or anaphylactic reaction with sudden signs such as rash, itching or hives on the skin, difficulties in swallowing, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble breathing, extreme tiredness (you may feel you are going to faint). In the majority of cases, these symptoms occurred during the infusion or immediately after but delayed allergic reactions have also been observed hours or even days after the infusion. - Pain in the chest or upper back, difficulty breathing and coughing up blood (symptoms of clots in the lung). Uncommon (may affect up to 1 in 100 people) : Serious infection of the blood (sepsis), which may be fatal. - Blockage or swelling of the bowel. - Difficulty in hearing, vertigo, ringing in e

Known drug interactions: 5-fluorouracil , Erythromycin, Salicylates, Granisetron , Paclitaxel , Sodium valproate.

Adults : Metastatic colorectal cancer : 85mg/m2 every 2 wk by IV infusion over 2-6 hr prior to administration of 5-FU. Stage III colon cancer : 85mg/m2 every 2 wk by IV infusion over 2-6 hr prior to administration of 5-FU . Children : Not recommended . OR As directed by your physician.

Active ingredient: Oxaliplatin. Labelled strength: 50mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Eloxitan Pharmaceuticals (Pvt) Ltd.. Country of origin: Pakistan.