Edonax Injection 5mg100ml

What it is used for: Osteoporosis.

Indications as listed by the manufacturer: It is used: To prevent bone complications, e.g. fractures, in adult patients with bone metastases (spread of cancer from primary site to the bone) ; To reduce the amount of calcium in the blood in adult patients where it is too high due to the presence of a tumour. Tumours can accelerate normal bone change in such a way that the release of calcium from bone is increased. This condition is known as tumour-induced hypercalcaemia (TIH).

How it works: Zoledronic acid belongs to the class of bisphosphonates and acts primarily on bone. It is an inhibitor of osteoclastic bone resorption. The selective action of bisphosphonates on bone is based on their high affinity for mineralised bone, but the precise molecular mechanism leading to the inhibition of osteoclastic activity is still unclear. In long-term animal studies, zoledronic acid inhibits bone resorption without adversely affecting the formation, mineralisation or mechanical properties of bone. In addition to being a potent inhibitor of bone resorption, zoledronic acid also possesses several anti-tumour properties that could contribute to its overall efficacy in the treatment of metastatic bone disease.

Active ingredient: Zoledronic Acid.

Reported side effects: Severe kidney impairment , Low level of calcium in the blood , Pain in the mouth, teeth and/or jaw, swelling or non-healing sores inside the mouth or jaw, discharge, numbness or a feeling of heaviness in the jaw, or loosening of a tooth , Irregular heart rhythm (atrial fibrillation) , Severe allergic reaction: shortness of breath, swelling mainly of the face and throat , As a consequence of low calcium values: irregular heart beat (cardiac arrhythmia; secondary to hypocalcaemia). - A kidney function disorder called Fanconi syndrome (will normally be determined by your doctor with certain urine tests).

Known drug interactions: Aminoglycosides , calcitonin , loop diuretics or other calcium-lowering medicines, Thalidomide or any other medicines which may harm your kidneys. - Any other medicine that also contains zoledronic acid and is used to treat osteoporosis and other non-cancer diseases of the bone, or any other bisphosphonate, Anti-angiogenic medicines .

Prevention of skeletal related events in patients with advanced malignancies involving bone : Adults and older people : The recommended dose in the prevention of skeletal related events in patients with advanced malignancies involving bone is 4 mg zoledronic acid every 3 to 4 weeks. Patients should also be administered an oral calcium supplement of 500 mg and 400 IU vitamin D daily. Treatment of TIH : Adults and older people : The recommended dose in hypercalcaemia (albumin-corrected serum calcium = 12.0 mg/dl or 3.0 mmol/l) is a single dose of 4 mg zoledronic acid. Children : The safety and efficacy of zoledronic acid in children aged 1 year to 17 years have not been established. Not Recommendeed.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Zoledronic Acid. Labelled strength: 5MG/100ML.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Edonax Laboratories (Pvt) Ltd.. Country of origin: Switzerland.