Deprel 50mg Tablets 30s

What it is used for: Depression.

Indications as listed by the manufacturer: It is used to treat all type of depression including depression accompanied by anxiety.

How it works: Trazodone HCl inhibits serotonin uptake into rat brain synaptosomes and by rat platelets at relatively high concentrations and inhibits brain uptake of noradrenaline in vitro only at very high concentrations. It possesses antiserotonin-adrenergic blocking and analgesic effects. The anticholinergic activity of trazodone is less than that of the tricyclic antidepressants in animal studies and this has been confirmed in therapeutic trials in depressed patients.

Active ingredient: Trazodone HCl.

Reported side effects: Thoughts of harming or killing yourself • Feeling tired, faint, dizzy, having pale skin. These could be signs of anaemia • Convulsions, fits (seizures) • Unusual skin sensations such as numbness, tingling, pricking, burning or creeping on the skin (paraesthesia) • Feeling confused, restless, sweating, shaking, shivering, hallucinations (strange visions or sounds), sudden jerks of the muscles or a fast heartbeat, you may have something called Serotonin syndrome • Feeling very unwell possibly with shortness of breath (dyspnoea), difficulty in walking or walking with a shuffling gait, shaking, uncontrolled muscle twitching and a high temperature (above 38°C). This could be a rare condition known as Neuroleptic Malignant Syndrome • Rapid, slow or irregular heartbeat.

Known drug interactions: MAOI (Mono Amine Oxidase Inhibitors) medicines such as tranylcypromine, phenelzine and isocarboxazid (for depression) or selegiline (for Parkinson’s disease) , Muscle relaxants and inhaled anaesthetics , Other antidepressants such as amitriptyline or fluoxetine , Sedatives such as tranquilizers and sleeping pills , Medicines used to treat epilepsy (e.g. carbamazepine or phenytoin) , Medicines used to treat high blood pressure (e.g. clonidine) or heart disease (e.g. digoxin) , Medicines used to treat fungal infections such as ketoconazole and itraconazole , Some medicines used to treat HIV such as ritonavir and indinavir , Erythromycin (a type of antibiotic used to treat infections) , Levodopa (used for Parkinson’s disease) , St. John’s Wort (a herbal medicine) , Warfarin (a drug used to stop blood from clotting) , Phenothiazines: chlorpromazine, fluphenazine, levomepromazine, perphenazine.

Adults : Initially 150mg daily taken in divided doses after meals or as a single night-time dose. May be increased after 1 wk to 300mg daily. Max 600mg daily. Elderly : Initially 100mg daily in divided doses after meals or as a single night time dose. Max 300mg daily. Children : Not Recommended. OR As directed by your physician .

Active ingredient: Trazodone HCl. Labelled strength: 50mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Deprel Laboratories (Pvt) Ltd.. Country of origin: Pakistan.