Danzol Capsules 100mg 30s

What it is used for: Endometriosis.

Indications as listed by the manufacturer: It is indicated for the treatment of endometriosis associated symptoms and/or to reduce the extent of endometriotic foci. It may be used either in conjunction with surgery or, as sole hormonal therapy, in patients not responding to other treatments.

How it works: Danazol, 17a-pregna-2,4-dien-20-yno(2,3-d)-isoxazol-17-ol, is a synthetic steroid derived from ethisterone. Its pharmacological properties include: 1. Relatively marked affinity for androgen receptors, less marked affinity for progesterone receptors and least affinity for oestrogen receptors. Danazol is a weak androgen but in addition antiandrogenic, progestogenic, antiprogestogenic, oestrogenic and antioestrogenic actions have been observed. 2. Interference with the synthesis of gonadal steroids, possibly by inhibition of the enzymes of steroidogenesis, including 3ß hydroxysteroid dehydrogenase,17ß hydroxysteroid dehydrogenase, 17 hydroxylase, 17, 20 lyase, 11ß hydroxylase, 21 hydroxylase and cholesterol side chain cleavage enzymes, or alternatively by inhibition of the cyclic AMP accumulation usually induced by gonadotrophic hormones in granulosa and luteal cells. 3. Inhibition of the mid-cycle surge of FSH and LH as well as alterations in the pulsatility of LH. Danazol can also reduce the mean plasma levels of these gonadotrophins after the menopause. 4. A wide range of actions on plasma proteins, including increasing prothrombin, plasminogen, antithrombin III, alpha-2 macroglobulin, C1 esterase inhibitor, and erythropoietin and reducing fibrinogen, thyroid binding and sex hormone binding globulins. Danazol increases the proportion and concentration of testosterone carried unbound in plasma. 5 The suppressive effects of danazol on the hypothalmic-pituitary-gonadal axis are reversible, cyclical activity reappearing normally within 60-90 days after th

Active ingredient: Danazol.

Reported side effects: Allergic: urticaria, pruritus, rarely nasal congestion; Skin and mucous membranes: rashes (maculopapular, vesicular, papular, purpuric, petechial), acne, hyperpigmentation, hair loss, inflammatory erythematous nodules, altered skin pigmentation, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome and rarely sun sensitivity; Gastrointestinal: nausea, vomiting, constipation, gastroenteritis and rarely pancreatitis; Genitourinary: hematuria, prolonged post-therapy amenorrhea, disturbance of the menstrual cycle, intermenstrual spotting and/or prolonged anovulation.

Known drug interactions: Coumadin (warfarin)-type anticoagulants ; carbamazepine, phenytoin and phenobarbital ; cyclosporin and tacrolimus (used to reduce organ rejection after an organ transplant operation) ; insulin or oral hypoglycemic agents (used to treat diabetes) ; anti-hypertensive drugs (used to treat high blood pressure) ; statin drugs (used to lower blood cholesterol such as simvastatin, atorvastatin and lovastatin). The concomitant administration with simvastatin is contraindicated.

Endometriosis: Clinical effectiveness has been achieved with total daily doses ranging from 200 to 800 mg in two to four divided doses and administered without interruption for 3 to 6 months . In patients with severe presenting symptomatology, the usual starting dose is 800 mg daily. The maximum recommended daily dose is 800 mg. It is essential that therapy continue uninterrupted for 3 to 6 months. Fibrocystic Breast Disease: The total daily dose ranges from 100 to 400 mg given in two divided doses depending upon patient response.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Danazol. Labelled strength: 100mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Danzol Pharma (Pvt) Ltd.. Country of origin: India.