Cytotrexate 10mg 10 Tablets

What it is used for: Cancer.

Indications as listed by the manufacturer: It is used in high doses to treat certain types of cancers, including breast cancer, Non-Hodgkin's lymphoma and leukemia.

How it works: Methotrexate is a cytostatic that inhibits cell growth. Methotrexate has its greatest effect on cells which increase frequently like cancer cells, bone marrow cells and skin cells.

Active ingredient: Methotrexate.

Reported side effects: The most common side effects include: Upset stomach, stomach pain, vomiting, nausea, loss of appetite, dizziness, chills and fever, diarrhea or sores on lips or mouth , A fall in the number of white blood cells. This may reduce your resistance to infection and increase your chances of cold sores, blood poisoning or swelling of blood vessels , Tiredness (fatigue) . Less common side effects are: Headaches, hair loss, mood changes, confusion, ringing in the ears, sore eyes, skin rashes, increased sensitivity to sunlight or unexplained weight loss , A fall in the number of other blood cells. This may increase your chances of bruising, bleeding or tiredness , Damage to the lungs , Harm to the unborn baby , Convulsions . Rarely, Methotrexate Injection USP can cause other side effects including: Liver damage, kidney damage, pain or difficulty urinating, lower back or side pain, blood in urine or stools, dark urine , Fits, blurred vision, short term blindness , Drowsiness, weakness , Hoarseness , Bloody vomit, black, tarry stools or pin-point red spots on the skin , Reddening or whitening of the skin, acne, boils, itching yellow skin or eyes , Impotence or loss of interest in sex, decreased fertility, abortion , Diabetes, thinning of the bones, painful muscles and joints , Low blood pressure , Gastrointestinal ulcers.

Known drug interactions: NSAIDs and salicylates , cisplatin, cytarabine, mercaptopurine) , antibiotics such as penicillins, tetracycline, ciprofloxacin and chloramphenicol) , theophylline) , Vitamin preparations containing folic acid or substances like folic acid , leflunomide , furosemide , probenicide , omeprazole, pantoprazole, lanzoprazol , Epilepsy (phenytoin) , retinoids, such as acitretin or isotretinoin , sulphsalazine , azathioprine , if you need to be vaccinated with a live vaccination.

Adults : Antineoplastic : Burkitt's Lymphoma : Stages I-II : Orally 10-25mg/day for 4-8 day for several courses ; separate by 7-10 day rest period . Lymphosarcomas : Stage III : Orally : 0.625-2.5mg/kg/day. Leukaemia : Induction : 3.3mg/m2 with prednisolone every day. Remission maintenance : 15mg/m2 Orally/IM twice weekly or 2.5mg/kg IV every 14 day. Children : Meningeal leukaemias : Intrathecal : Dilute preservative free methotraxate to 1mg/ml. Dose every 2-5 day . >3yr : 12mg . 2 yr : 10mg. 1yr : 8mg . <1yr : 6mg. Juvenile rheumatoid arthritis : Children : 2-16 yr : 10mg/m2 once weekly. Adjust dose to optimal response. OR As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Methotrexate. Labelled strength: 10MG.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Cytotrexate Laboratories (Pvt) Ltd.. Country of origin: Switzerland.