Co Trupril Tablets 2012/5mg 28s

What it is used for: Hypertension.

Indications as listed by the manufacturer: It is indicated in the management of mild to moderate hypertension in patients who are not adequately controlled on monotherapy.

How it works: Lisinopril : The mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. Lisinopril is antihypertensive even in patients with low-renin hypertension. Hydrochlorothiazide : The mechanism of the antihypertensive effect of thiazides is unknown. Thiazides do not usually affect normal blood pressure. Hydrochlorothiazide is a diuretic and antihypertensive. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume with consequent increase in plasma renin activity increase in aldosterone secretion, increases in urinary potassium loss and decrease in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics .

Active ingredient: Lisinopril , Hydrochlorothiazide.

Reported side effects: Common : Dizziness, headache, dry cough, fatigue, hypotension including orthostatic hypotension. Small decreases in hemoglobin and haematocrit. Less Common : Diarrhea, nausea, vomiting, dry mouth, rash, gout, palpitations, chest discomfort, muscle cramps and weakness, paraesthesia, asthenia and impotence, hyperglycemia, hyperuricemia and hyper or hypokalemia. Rarely : Pancreatitis, agranulocytosis, elevations of liver enzymes and/or serum bilirubin.

Known drug interactions: Agents Increasing Serum Potassium , Agents Affecting Sympathetic Activity , Lithium , Corticosteroids (ACTH) , Nonsteroidal Anti-inflammatory Drugs , Tubocurarine , Insulin , Alcohol, Barbiturates or Narcotics , Pressor Amines .

Adults : The usual dosage of Lisinopril+Hydrochlorothiazide is 1 tablet, administered once daily. It should be taken approximately the same time each day. If the desired therapeutic effect cannot be achieved in a period of 2 to 4 weeks at this dose level, the dose can be increased to 2 tablets administered once daily . Children : Not recommernded. OR As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Lisinopril , Hydrochlorothiazide. Labelled strength: 20mg+12.5mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Co Trupril Healthcare (Pvt) Ltd.. Country of origin: Germany.