Co Tasmi Tablets 8012/5mg 14s

What it is used for: Hypertension.

Indications as listed by the manufacturer: It is indicated for the treatment of hypertension.

How it works: Telmisartan : Telmisartan is an orally effective and specific angiotensin II receptor subtype 1 (AT1) antagonist. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensinconverting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis. In patients with hypertension telmisartan reduces both systolic and diastolic blood pressure without affecting pulse rate. Telmisartan has much greater affinity (>3,000 fold) for the AT1 receptor than for the AT2 receptor. Hydrochlorothiazide : Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity, increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium. Presumably through blockade o f the renin-angiotensin-aldosterone system, co-administration of telmisartan tends to reverse the potassium loss associated with thiazide diuretics.

Active ingredient: Telmisartan + Hydrochlorothiazide.

Reported side effects: Common: Dizziness Uncommon: Hypokalemia, anxiety, syncope, paraesthesia, vertigo, tachycardia, arrhythmias, hypotension, or thostatic hypotension, dyspnoea, diarrhea, dry mouth, flatulence, back pain, muscle spasms, myalgia, erectile dysfunction, chest pain and blood uric acid increase. Rare: Bronchitis, hyperuricemia, hyponatremia, depression, insomnia, sleep disorders, visual disturbance, vision blurred, respiratory distress, abdominal pain, constipation, dyspepsia, vomiting, abnormal hepatic function/liver disorder, angioedema, muscle cramp, pain in limb, influenza-like illness, pain, blood creatinine increased, blood creatine phosphokinase increased and hepatic enzyme increased.

Known drug interactions: Lithium , Digoxin , kaliuretic diuretics, laxatives, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G sodium, salicylic acid and derivatives) , ACE inhibitors, potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium, cyclosporine or other medicinal p roducts such as heparin sodium) , quinidine, hydroquinidine, disopyramide), class III antiarrythmics (e.g, amiodarone, sotalol,dofetilide, ibutilide), some antipsychotics : (e.g., thioridazine, chlorpromazine, levomepromazine, trifluoperazine, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol), others: (e.g., bepridil, cisapride, diphemanil, erythromycin IV, halofantrin, mizolastin, pentamidine, sparfloxacine, terfenadine, vincamine IV.) , Metformin , Cholestyramine and colestipol resins , NSAIDs , Amantadine ,Cytotoxic agents (e.g., cyclophosphamide, methotrexate).

Adults : Usually effective dose of telmisartan is 40mg once daily. Blood response is dose related over the range of 20-80mg. Some patients may already benefit at a daily dose of 20mg. Hydrochlorothiazide is effective in doses of 12.5mg to 50mg once daily. Renal impaired patients : The usual regimens of therapy with Telmisartan + Hydrochlorothiazide may be followed as long as the patient’s creatinine clearance is >30mL/min. In patients with more severe renal impairment it is not recommended to use thiazide. Hepatic impaired patients In patients with mild to moderate hepatic impairment the dosage should not exceed 40mg+12.5mg once daily or as directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Telmisartan + Hydrochlorothiazide. Labelled strength: 12.5mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Co Tasmi Laboratories (Pvt) Ltd.. Country of origin: Pakistan.