Clozaril 100mg Tablets

What it is used for: Schizophrenia.

Indications as listed by the manufacturer: Treatment-resistant schizophrenia ; it is indicated in adult patients with treatment-resistant schizophrenia, i.e. patients with schizophrenia who are non-responsive to or intolerant of classic antipsychotics.

How it works: Clozapine has been shown to be an antipsychotic agent that is different from classic antipsychotics. In pharmacological experiments, the compound does not induce catalepsy or inhibit apomorphine- or amphetamine-induced stereotyped behaviour. It has only weak dopamine-receptor-blocking activity at D1, D2, D3 and D5 receptors, but shows high potency for the D4 receptor. Clozaril has potent anti-alpha-adrenergic, anticholinergic, antihistaminic, and arousal-reaction-inhibiting effects. It has also been shown to possess antiserotoninergic properties.

Active ingredient: Clozapine.

Reported side effects: Severe constipation , Fast heart beat , signs of a cold, fever, flu-like symptoms, sore throat or any other infection , seizures , sudden fainting or sudden loss of consciousness with muscle weakness (syncope) , signs of a respiratory tract infection or pneumonia such as fever, coughing, difficulty breathing, wheezing , severe, burning, upper abdominal pain, extending to the back accompanied by nausea and vomiting due to inflammation of the pancreas , fainting and muscle weakness due to a significant drop in blood pressure (Circulatory collapse) , difficulty in swallowing (which may cause inhalation of food) , nausea (feeling sick), vomiting (being sick) and/or loss of appetite , interruption in breathing with or without snoring during sleep , signs of becoming obese or increasing obesity

Known drug interactions: Carbamazepine , chloramphenicol, sulphonamides , pyrazolone analgesics such as phenylbutazone , lithium, fluvoxamine, tricyclic antidepressants, MAO inhibitors, citalopram, paroxetine, fluoxetine, and sertraline , perazine , warfarin , digoxin , omeprazole or cimetidine , erythromycin and rifampicin , atropine , adrenaline

The initial dose should be 12.5 mg given once on the first day, and dosage increase should be slow and in small increments. Starting therapy: Clozapine should be started with 12.5 mg (half a 25 mg tablet) once or twice on the first day, followed by one or two 25 mg tablets on the second day. If well tolerated, the daily dose may then be increased slowly in increments of 25 mg to 50 mg in order to achieve a dose level of up to 300 mg/day within 2 to 3 weeks. Thereafter, if required, the daily dose may be further increased in increments of 50 mg to 100 mg at half-weekly or, preferably, weekly intervals. Therapeutic dose range: In most patients, antipsychotic efficacy can be expected with 200 to 450 mg/day given in divided doses. Some patients may be treated with lower doses, and some patients may require doses up to 600 mg/day. The total daily dose may be divided unevenly, with the larger portion being taken at bedtime. Maximum dose: To obtain full therapeutic benefit, a few patients may require larger doses, in which case judicious increments (not exceeding 100 mg) are permissible up to 900 mg/day. The possibility of increased adverse reactions (in particular seizures) occurring at doses over 450 mg/day must be borne in mind.

Active ingredient: Clozapine. Labelled strength: 100mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Clozaril Pharma (Pvt) Ltd.. Country of origin: Pakistan.