Ciafil Tablets 5mg 4 Tablets

What it is used for: Male Infertility.

Indications as listed by the manufacturer: Treatment of erectile dysfunction in adult males .It i is also indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).

How it works: Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation. The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The mechanism for reducing BPH symptoms has not been established.

Active ingredient: Tadalafil.

Reported side effects: Body as a Whole : Asthenia, face edema, fatigue, pain ; Cardiovascular : Angina pectoris, chest pain, hypotension, myocardial infarction, postural hypotension, palpitations, syncope, tachycardia ; Digestive : Abnormal liver function tests, dry mouth, dysphagia, esophagitis, gastritis, GGTP increased, loose stools, nausea, upper abdominal pain, vomiting, gastroesophageal reflux disease, hemorrhoidal hemorrhage, rectal hemorrhage ; Musculoskeletal : Arthralgia, neck pain ; Nervous : Dizziness, hypesthesia, insomnia, paresthesia, somnolence, vertigo ; Renal and Urinary : Renal impairment ; Respiratory : Dyspnea, epistaxis, pharyngitis ; Skin and Appendages : Pruritus, rash, sweating ; Ophthalmologic : Blurred vision, changes in color vision, conjunctivitis (including conjunctival hyperemia), eye pain, lacrimation increase, swelling of eyelids ; Otologic : Sudden decrease or loss of hearing, tinnitus ; Urogenital : Erection increased, spontaneous penile erection .

Known drug interactions: An alpha blocker (used to treat high blood pressure or urinary symptoms associated with benign prostatic hyperplasia) , other medicines to treat high blood pressure , riociguat , a 5- alpha reductase inhibitor (used to treat benign prostatic hyperplasia) , medicines such as ketoconazole tablets (to treat fungal infections) and protease inhibitors for treatment of AIDS or HIV infection , phenobarbital, phenytoin and carbamazepine (anticonvulsant medicines) , rifampicin, erythromycin , clarithromycin or itraconazole , other treatments for erectile dysfunction.

Use as Needed for Erectile Dysfunction : The recommended starting dose is 10 mg .The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability ; For Once Daily Use for Erectile Dysfunction : The recommended starting dose for once daily use is 2.5 mg, taken at approximately the same time every day . The dose for once daily use may be increased to 5 mg , based on individual efficacy and tolerability ; For Once Daily Use for Benign Prostatic Hyperplasia : The recommended dose for once daily use is 5 mg, taken at approximately the same time every day ; For Once Daily Use for Erectile Dysfunction and Benign Prostatic Hyperplasia : The recommended dose for once daily use is 5 mg . Or As directed by your physician.

Active ingredient: Tadalafil. Labelled strength: 5mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Ciafil Pharma (Pvt) Ltd.. Country of origin: United Arab Emirates.