Busron Tablets 5mg 3x10s

What it is used for: Anxiety.

Indications as listed by the manufacturer: Buspirone used for the: • Short term management of anxiety disorders • Relief of symptoms of anxiety with or without symptoms of depression.

How it works: Buspirone is a member of the azapirone class of drugs. It has anxiolytic activity, but is largely lacking in sedative and muscle relaxant effects and anticonvulsant activity. Its mechanism of action has yet to be fully explained. Evidence to date suggests that its activity is based on its effects on serotonin (5-HT) receptors. It acts as an agonist of pre-synaptic and partial agonist of post-synaptic 5-HT1A subtype receptors. It is thought this initiates long-term changes in central 5-HT neurotransmission, producing the efficacy seen in the treatment of anxiety. Buspirone is thought to have antagonist activity at D2 receptors at the doses stipulated for anxious disorders, though it is unclear if this is linked to its anxiolytic activity. Buspirone's effects on GABAergic mechanisms are unclear. It does not directly interact with either the benzodiazepine-GABA receptor complex or GABA receptors. However, there is indirect evidence for buspirone having a GABA antagonist-like action.

Active ingredient: Buspirone.

Reported side effects: Nervousness, difficulty in sleeping, disturbance in attention, depression, confused state, sleeping problems, anger, excitement, pins and needles, tingling, blurred vision, abnormal coordination, tremor, ringing or buzzing in the ears, racing heart (abnormally fast heart rhythm), chest pain, blocked nose, sore throat, feeling and being sick, stomach pain, dry mouth, diarrhoea, constipation, cold sweats, rash, pain in the muscles, tendons, ligaments and bone, mental and physical tiredness .

Known drug interactions: Monoamine-oxidase inhibitors (MAOIs) such as phenelzine, tranylcypromine (for depression) • St. John’s Wort, nefazodone, L-tryptophan, fluvoxamine, trazodone (for depression) • Selective serotonin re-uptake inhibitors (SSRIs) e.g. fluoxetine, paroxetine (for depression) • Serotonin norepinephrine re-uptake inhibitors (SNRIs) e.g. duloxetine, venlafaxine • Tricyclic antidepressants e.g. amitriptyline, clomipramine • Haloperidol, lithium (for mental illness) • Calcium channel blockers such as diltiazem, verapamil (to treat high blood pressure) • Rifampicin (to treat tuberculosis) • Triptan drugs e.g. sumatriptan (to treat migraine) • Tramadol (a painkiller) • Baclofen (a muscle relaxant) • Lofexidine (to manage drug withdrawal) • Nabilone (to treat nausea and vomiting) • Antihistamines (to treat allergic reactions) • Erythromycin, itraconazole, linezolid (to treat infections) • Benzodiazepines e.g. nitrazepam or temazepam or another common sedative or hypnotic medicine • Diltiazem (to treat angina) • Digoxin (to treat hea

Adults (including the elderly) : The usual starting dose is 5mg two to three times a day, which may be increased every two to three days. The usual dose you will be maintained on is 15mg to 30mg a day in divided doses. The maximum daily dosage should not exceed 60mg per day. Use in children and adolescents : Buspirone are not recommended for use in children or adolescents under the age of 18. OR As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Buspirone. Labelled strength: 5mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Busron Healthcare (Pvt) Ltd.. Country of origin: Pakistan.