Brivera 100mg Tablets 14s

What it is used for: Epilepsy.

Indications as listed by the manufacturer: It is used to treat • A type of epilepsy that has partial seizures with or without a secondary generalisation. • Partial seizures are fits that start by only affecting one side of the brain. These partial seizures can spread and extend to larger areas on both sides of the brain – this is called a ‘secondary generalisation’.

How it works: Brivaracetam displays a high and selective affinity for synaptic vesicle protein 2A (SV2A), a transmembrane glycoprotein found at presynaptic level in neurons and in endocrine cells. Although the exact role of this protein remains to be elucidated it has been shown to modulate exocytosis of neurotransmitters. Binding to SV2A is believed to be the primary mechanism for brivaracetam anticonvulsant activity.

Active ingredient: Brivaracetam.

Reported side effects: Feeling sleepy or dizzy , flu , feeling very tired (fatigue) , convulsion, a feeling of ‘spinning’ (vertigo) , feeling and being sick, constipation , depression, anxiety, not being able to sleep (insomnia), irritability , infections of the nose and throat (such as the ‘common cold’), cough , decreased appetite , allergic reactions , abnormal thinking and/or loss of touch with reality (psychotic disorder), being aggressive, nervous excitement (agitation) , thoughts or attempts of harming or killing yourself: tell your doctor straight away , a decrease in white blood cells (called ‘neutropenia’) - shown in blood tests .

Known drug interactions: Rifampicin , St John’s wort (also known as Hypericum perforatum) , CYP2C19 strong inhibitors (e.g. fluconazole , fluvoxamine) , Carbamazepine , phenobarbital , phenytoin , lonafarnib , metoclopramide, selinexor.

Adults, adolescents and children weighing 50 kg or more - The recommended dose is from 25 mg to 100 mg taken twice a day . Your doctor may then decide to adjust your dose to find the best dose for you. Children and adolescents weighing less than 50 kg - The recommended dose is from 0.5 mg to 2 mg for each kg of bodyweight, taken twice a day. Your doctor may then decide to adjust your dose to find the best dose for you. OR As directed by your physician.

Active ingredient: Brivaracetam. Labelled strength: 100mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Brivera Pharmaceuticals (Pvt) Ltd.. Country of origin: Pakistan.