Brexin Tablets 20mg 30 Tablets

What it is used for: Pain & Inflammation.

Indications as listed by the manufacturer: It is indicated for a variety of acute painful conditions requiring anti-inflammatory and analgesic activity, including rheumatoid arthritis, osteo-arthritis (arthrosis, degenerative joint disease), ankylosing spondylitis, musculoskeletal and joint disorders, gout, in soft-tissue disorders and in post-operative pain.

How it works: Piroxicam an NSAID complex with cyclodextrin, possess analgesic and antipyretic properties, the complex allows single molecule of NSAID to be released adjacent to the gastrointestinal mucosa, instead of crystals. Since the time contact with gastric mucosa is reduced, the risk of direct contact gastric irritation is also reduced.

Active ingredient: Piroxicam beta cyclodextrin.

Reported side effects: Very common: Nausea, epigastric distress, abdominal pain and discomfort, flatulence, constipation and diarrhea. Other possible reactions are hypersensitivity signs, such as skin rash, headache, vertigo, asthenia, blood chemistry modifications, and increase in blood urea. Less common: Vomiting, allergic oedema of the face and hands, blurred vision, tinnitus, aplastic anaemia, leucopoenia, eosinophilia, pancytopenia, thrombocytopenia, increase in parameters of liver functions, jaundice, acute renal insufficiency, water retention that may occur in the form of edema (mainly ankle edema), or cardiocirculatory disorders hypertension, congestive heart failure). Sporadic cases of gastric ulcer with perforation, Stevens-Johnson's syndrome, Lyell’s syndrome-, agranulocytosis, bladder disorders, shock and warning symptoms, acute heart failure. Stomatitis, alopecia and nail growth disorders have been reported. Rare: Gastric ulcers and hemorrhages may also occur.

Known drug interactions: Warfarin , Protein bound drugs , Methotrexate , Aspirin and other NSAIDs , Plasma lithium concentrations , Diuretics , Anti-hypertensives , Cardiac Glycosides , Quinolone Antibiotics , Mifepristone , Cyclosporine , Aminoglycosides , Oral Hypoglycemic Agents.

Oral : In rheumatic disorders a usual initial dose of this medicine is 20mg daily as a single dose. In acute musculoskeletal conditions an initial dose of 40mg daily may be given for 2 days followed by 20mg daily for a total of 1 to 2 weeks. It is also used in acute gout, the usual dose being 40mg daily for 5 to 7 days. OR As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Piroxicam beta cyclodextrin. Labelled strength: 20mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Brexin Pharma (Pvt) Ltd.. Country of origin: Switzerland.