Adoxa Tablets 30s

What it is used for: Bacterial Infection.

Indications as listed by the manufacturer: It is used to treat a wide range of infections caused by bacteria, these include: • Chest, lung or nasal infections e.g. bronchitis, pneumonia, sinusitis • Infections of the kidneys and bladder e.g. cystitis, urethritis • Infections of the skin such as acne • Eye infections • Sexually transmitted diseases e.g. gonorrhoea, syphilis, chlamydia • Rickettsial infections such as Q fever or fevers associated with louse or tick bites • Malaria, when chloroquine is not effective • Other infections such as cholera, brucellosis, leptospirosis and psittacosis

How it works: The main mechanism of action of doxycycline is on protein synthesis. Doxycycline passes directly through the lipid bilayer of the bacterial cell wall and an energy dependent active transport system pumps the drug through the inner cytoplasmic membrane. Once inside the cell doxycycline inhibits protein synthesis by binding to 30S ribosomes and prevents the addition of amino acids to the growing peptide chain. Doxycycline will impair protein synthesis in mammalian cells at very high concentrations but these cells lack the active transport system found in bacteria.

Active ingredient: Doxycycline (as Hyclate).

Reported side effects: Sensitivity to sunlight - you may get a skin rash, itching, redness or severe sunburn when out in sunlight or after using a sun bed (Photosensitivity reaction) • Increased pressure in the skull (severe headaches, blurred and/or double vision, blind spots, permanent loss of vision) (Peripheral oedema) • Headache • Low blood pressure (Hypotension) • Nausea/vomiting • Rashes (consisting of flat or raised red, brown or pink lesions) • Inflammation of small blood vessels (Henoch-Schonlein purpura) • Hives (Urticaria) • Increased heart rate (Tachycardia) • Shortness of breath or breathlessness (Dyspnoea) • Blood disorders (symptoms may include tiredness, weakness, easy bruising or susceptibility to infection) • The Jarisch-Herxheimer reaction which causes fever, chills, headache, muscle pain and skin rash that is usually self-limiting. This occurs shortly after starting doxycycline treatment for infections with spirochete such as Lyme disease. • Porphyria (sensitivity of the skin to sunlight, inflammation of nerves and stomach pains) • Discolouration of thyroid tissue (does not affect thyroid function) • Decreased appetite • Bulging fontanelles (soft spot on head) of infants • Anxiety • Flushing

Known drug interactions: Penicillin antibiotics , Rifampicin , warfarin , Quinapril , Oral contraceptives , Phenobarbital , Carbamazepine, phenytoin, primidone , Ciclosporin , Methoxyflurane , Methotrexate , antacids (indigestion tablets or liquids) containing aluminium, calcium, magnesium or other medicines containing iron, bismuth or zinc salts , Retinoids .

Lower Respiratory Infections : Adults - 100mg every 12hr on day 1 then 100mg once daily or 50mg every 12hr. Severe : 100mg every 12hr. Children : >8yr old & <100lbs body weight : 1mg/lb every 12hr on day 1 , then 1mg/lb once daily or 0.5mg/lb every 12hr on day 1, then 1mg/lb once daily or 0.5mg/lb every 12 hr. Severe : 2mg/lb. >100lbs body weight : Adult dose. Always take your medicine exactly as your doctor has instructed you. You should check with your doctor or pharmacist, if you are unsure.

Active ingredient: Doxycycline (as Hyclate). Labelled strength: 100mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Adoxa Healthcare (Pvt) Ltd.. Country of origin: United Kingdom.