Abocain Spinal Injection 75mg 2ml

What it is used for: Anesthesia.

Indications as listed by the manufacturer: It is indicated for the production of subarachnoid block (spinal anaesthesia).

How it works: Local anaesthetics block the generation and the conduction of nerve impulses presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential. In general, the progression of anaesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows : (1) pain, (2) temperature. (3) touch. (4) proprioception and (5) skeletal muscle tone. Systemic absorption of local anaesthetics produce effects on the cardiovascular and central nervous system (CNS). At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.

Active ingredient: Bupivacaine Hydrochloride.

Reported side effects: The most commonly encountered acute of those adverse experiences which demand immediate countermeasures following the administration of spinal anaesthesia are hypertension due to loss of sympathetic tone and respiratory paralysis or underventilation due to cephalad extension of the motor level of anaesthesia. These may lead to cardiac arrest if untreated. In addition, dose related convulsions and cardiovascular collapse may result from diminished tolerance, rapid absorption from the injection site or from unintentional intravascular injection of a local anaesthetic solution Factors influencing plasma protein binding, such as acidosis, systemic disease which alter protein production, or competition of other drugs for protein binding sites, may diminish individual tolerance.

Known drug interactions: The administration of local anaesthetic solutions containing epinephrine or norepinephrine to patient receiving monoamine oxidase inhibitors or tricycilc antidepressants may produce severe, prolonged hypertension. Concurrent therapy is necessary, careful patient monitoring is essential. Concurrent administration of vasopressor drugs and of ergot-type oxytocic drugs may cause severe persistent hypertension or cerebrovascular accidents. Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.

Dose : According to patient's physical status and nature of procedure. Local infiltration : 0.25% (upto 60ml) .Peripheral nerve block : 0.25% (max 60ml) , 0.5% (max 30ml). Epidural block : Surgery , lumbar , 0.5% (max 20ml) , Surgery , caudal 0.5% (max 30ml). Children (upto 10yr) using 0.25% solution , upto lower thoracic (T10) 0.9-0.4ml/kg , upto mid thoracic (t6) 0.4-0.8ml/kg. Always consult your doctor or pharmacist for dose adjustments.

Active ingredient: Bupivacaine Hydrochloride. Labelled strength: 7.5mg/ml.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Abocain Healthcare (Pvt) Ltd.. Country of origin: Pakistan.