Tryptanol Tablets 25mg 10x10s

What it is used for: Depression.

Indications as listed by the manufacturer: This medicine is used to treat: • Depression in adults (major depressive episodes) • Neuropathic pain in adults • Chronic tension type headache prophylaxis in adults • Migraine prophylaxis in adults .

How it works: Amitriptyline is a tricyclic antidepressant and an analgesic. It has marked anticholinergic and sedative properties. It prevents the re-uptake, and hence the inactivation of noradrenaline and serotonin at nerve terminals. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity. The mechanism of action also includes ion-channel blocking effects on sodium, potassium and NMDA channel at both central and spinal cord level. The noradrenaline, sodium and the NMDA effects are mechanisms known to be involved in the maintenance of neuropathic pain, chronic tension type headache prophylaxis and migraine prophylaxis. The pain-reducing effect of amitriptyline is not linked to its anti-depressive properties.

Active ingredient: Amitriptyline HCl.

Reported side effects: Very common (may affect more than 1 in 10 people): • Sleepiness/drowsiness • Shakiness of hands or other body parts • Dizziness, headache, dizziness when you stand up due to low blood pressure (orthostatic hypotension) • Irregular, hard, or rapid heartbeat • Dry mouth, constipation, nausea • Excessive sweating • Weight gain • Slurred or slow speech • Aggression • Congested nose. Common: (may affect up to 1 in 10 people): • Confusion • sexual disturbances (decreased sex-drive, problems with erection) • disturbance in attention • changes in taste • numbness or tingling in the arms or legs • disturbed coordination • dilated pupils • heart block • fatigue • low sodium concentration in the blood • agitation • urination disorders • feeling thirsty. Uncommon (may affect up to 1 in 100 people): • Excitement, anxiety, difficulties sleeping, nightmares • convulsions • tinnitus • increased blood pressure • diarrhoea, vomiting • skin rash, nettle rash (urticaria), swelling of the face and tongue.

Known drug interactions: Monoamine oxidase inhibitors (MAOIs) e.g. phenelzine, iproniazid, isocarboxazid, nialamide or tranylcypromine (used to treat depression) or selegiline , adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine , calcium-channel blockers (e.g. diltiazem and verapamil), guanethidine, betanidine, clonidine, reserpine and methyldopa , atropine, hyoscyamine , thioridazine , nefopam, tramadol and morphine , buprenorphine , fungal infections (e.g. fluconazole, terbinafine, ketoconazole, and itraconazole) , sedatives (e.g. barbiturates) , antidepressants (e.g. SSRIs (fluoxetine, paroxetine, fluvoxamine), and bupropion) , medicines for certain heart conditions (e.g. beta blockers and antiarrhythmics) , cimetidine (used to treat stomach ulcers) , methylphenidate (used to treat ADHD) , ritonavir (used to treat HIV) .

Adults : Usually 75mg daily in divided doses increasing if required to 150mg daily. Maintenance , 50-100mg daily usually as a single dose at bedtime. Elderly : 50mg daily in divided doses or as a single dose at bedtime . Children : Depression : 16-18yr, 10-25mg 3 times daily ( total daily dose may alternatively be given as a single dose at bedtime ) increased gradually as necessary to 150-200mg daily. OR As directed by your physician.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Active ingredient: Amitriptyline HCl. Labelled strength: 25mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Tryptanol Healthcare (Pvt) Ltd.. Country of origin: United Kingdom.