Cutivate M Ointment 10g

What it is used for: Dermatitis.

Indications as listed by the manufacturer: It is indicated for adults, children and infants aged 3 months and over for the treatment of steroid-responsive inflammatory disorders of the skin where secondary bacterial infection is present, suspected or likely to occur. Ointment formulation is indicated in dry lesions.

How it works: Topical corticosteroids, have anti-inflammatory, antipruritic, and vasoconstrictive properties. They act as anti-inflammatory agents via multiple mechanisms to inhibit late phase allergic reactions including decreasing the density of mast cells, decreasing chemotaxis and activation of eosinophils, decreasing cytokine production by lymphocytes, monocytes, mast cells and eosinophils, and inhibiting the metabolism of arachidonic acid. Fluticasone propionate is a glucocorticoid with high topical anti-inflammatory potency but low HPA-axis suppressive activity after dermal administration. It therefore has a therapeutic index which is greater than most of the commonly available steroids. It shows high systemic glucocorticoid potency after subcutaneous administration but very weak oral activity, probably due to metabolic inactivation. In vitro studies show a strong affinity for, and agonist activity at, human glucocorticoid receptors. Fluticasone propionate has no unexpected hormonal effects, and no overt, marked effects upon the central and peripheral nervous systems, the gastrointestinal system, or the cardiovascular or respiratory systems.

Active ingredient: Fluticasone Propionate , Mupirocin.

Reported side effects: Local burning,erythema and pruritus , local atrophic changes in the skin such as thinning, striae, dilation of the superficial blood vessels, hypertrichosis and hypo pigmentation.

Known drug interactions: CYP3A4 Inhibitors (e.g. ritonavir, itraconazole) .

For adults, children and infants aged three months and over, apply a thin film to the affected areas twice daily for upto 10 days depending upon the response. OR As directed by your physician.

Active ingredient: Fluticasone Propionate , Mupirocin.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Cutivate Laboratories (Pvt) Ltd.. Country of origin: Pakistan.