Co Tritace Tablets 2/512/5mg 2x14s

What it is used for: Hypertension.

Indications as listed by the manufacturer: For the treatment of mild to moderate hypertension in patients (in whom combination therapy is appropriate) who have been stabilized on the individual components given in the same proportion .

How it works: Ramipril and hydrochlorothiazide has antihypertensive and diuretic effects. Ramipril and hydrochlorothiazide are used singly or together for antihypertensive therapy. The antihypertensive effects of both substances are complementary. The blood-pressure-lowering effects of both components together are greater than the effect of either monotherapy. In patients treated with ramipril and a thiazide diuretic there was essentially no change in serum potassium .

Active ingredient: Ramipril , Hydrochlorothiazide.

Reported side effects: Cadiovascular system: angina pectoris, hypotension, palpitation, postural hypotension, syncope, tachycardia. Digestive system: constipation, gastroenteritis, gastrointestinal pain, nausea. Metabolic and nutritional disorders: excessive thirst, gout, hyperglycemia, hyperuricemia, hypokalemia and peripheral edema. Musculo-skeletal system: arthralgia, myalgia,. Nervous system: anxiety, apathy, depression, dry mouth, hot flushes, nervousness, paresthesia, sleep disorder, somnolence, sweating and tremor. Respiratory system: dyspnea, and sinusitis. Skin and appendages: alopecia, angioedema, maculopapular rash, pruritus, psoriasis, rash. Special senses: conjunctivitis, taste loss, and tinnitus. Urogenital system: impotence, renal failure, kidney function abnormal.

Known drug interactions: ACE inhibitors , aliskiren-containing medicines , Angiotensin-II receptor antagonists (AIIRAs) , potassium-retaining diuretics (e.g. spironolactone), potassium salts , Vasopressor sympathomimetics , Allopurinol, immunosuppressants, corticosteroids, procainamide, cytostatics , Lithium salts , Antidiabetic agents (e.g. Insulin and sulfonylurea derivatives) , Vildagliptin , temsirolimus , Neprilysin (NEP) inhibitor , Nonsteroidal anti-inflammatory drugs (e.g. Indomethacin) and acetylsalicylic acid , Heparin , Corticosteroids, carbenoxolone, large amounts of liquorice, laxatives , Digitalis preparation , Alcohol.

Adult Initial dosage: 2.5mg ramipril/12.5mg hydrochlorothiazide daily. If necessary, the dose may be increased at intervals of 2 to 3 weeks. Maximum adult dose: 10 mg ramipril and 50 mg hydrochlorothiazide (corresponding to 4 tablets RAMIPRIL-HCTZ 2.5/12.5 or 2 tablets RAMIPRIL-HCTZ 5/25) . Children : It is not recommended for use in children and adolescents below 18 years of age due to insufficient data on safety and efficacy . OR As directed by your physician.

Active ingredient: Ramipril , Hydrochlorothiazide. Labelled strength: 12.5mg.

Store this medicine at room temperature, away from direct light and heat.

Manufactured by Co Tritace Pharma (Pvt) Ltd.. Country of origin: Switzerland.