2Sum Im/Iv Injection 1g (1 Box = 1 Injection)

The anti-bacterial component of sulbactam/cefoperazone is cefoperazone, a third generation cephalosporin, which acts against sensitive organisms during the stage of active multiplication by inhibiting biosynthesis of cell wall mucopeptide. Sulbactam does not possess any useful antibacterial activity, except against Neisseriaceae and Acinetobacter. However, biochemical studies with cell-free bacterial systems have shown it to be an irreversible inhibitor of most important beta-lactamases produced by beta-lactam antibiotic-resistant organisms.

Monotherapy : It is indicated for the treatment of the following infections when caused by susceptible organisms:i. Respiratory tract infections (upper and lower) ii. Urinary tract infections (upper and lower) iii. Peritonitis, cholecystitis, cholangitis, and other intra-abdominal infections iv. Septicaemia v. Meningitisvi. Skin and soft tissue infections vii. Bone and joint infections viii. Pelvic inflammatory disease, endometritis, gonorrhoea, and other infections of the genital tractCombination Therapy : Because of the broad spectrum of activity of Sulbactum/ Cefoperazone, most infections can be treated adequately with this antibiotic combination alone. However, Sulbactum/Cefoperazone may also be used concomitantly with other antibiotics if such combinations are indicated. If an aminoglycoside is used, renal function should be monitored during the course of therapy.

Adults : The usual adult dose of the combination is 2 to 4 g/day (i.e, 1-2 g/day each of Cefoperazone and Sulbactam given IV or IM in equally divided doses every 12 hours. In severe or refractory infections the daily dosage may be increased to 8g (i.e, 4g/day each of Cefoperazone and Sulbactam) given IV in equally divided doses every 12 hours. The recommended maximum daily dosage of Sulbactam is 4g (8g of the combination). Children : The usual dosage in children is 40-80mg/kg/day (20 to 40 mg/kg/day each of Cefoperazone and Sulbactam) every six to twelve hours. In serious or refractory infections, these dosages may be increased up to 240mg/kg/day (160 mg/kg/day cefoperazone activity). Doses should be administered in two to four equally divided doses.Use in Neonates : For neonates in the first week of life, the drug should be given every 12 hours. The maximum daily dosage of sulbactam in paediatrics should not exceed 80 mg/kg/day . Always consult your doctor or pharmacist for dose adjustments.

Follow your doctor’s instructions. The dosage above is the usual range — your prescription takes precedence over it.

Cefoperazone , Salbactam

Store this medicine at room temperature, away from direct light and heat.

Manufactured by SAMI PHARM (PVT) LTD.. Country of origin: Pakistan.